5810-55-9

Basic information

• Product Name: 3-ACETAMIDOPIPERIDINE
• Synonyms: N-PIPERIDIN-3-YL-ACETAMIDE;3-ACETAMIDOPIPERIDINE;3-(N-Acetylamino)piperidine;3-Acetylaminopiperidine;N-(3-Piperidinyl)acetamide;N-(3-piperidyl)acetamide;N-piperidin-3-ylethanamide
• CAS NO: 5810-55-9
• Molecular Formula: C₇H₁₄N₂O
• Molecular Weight: 142.2
• Mol File: 5810-55-9.mol
• Article Data: 4

Chemical Properties

• Melting Point: 81 °C
• Boiling Point: 318.5 °C at 760 mmHg
• Flash Point: 149.6 °C
• Appearance: /
• Density: 1.02
• Vapor Pressure: 0.000361mmHg at 25°C
• Refractive Index: 1.484
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• Solubility: soluble in Methanol
• PKA: 15.94±0.20(Predicted)
• CAS DataBase Reference: 3-ACETAMIDOPIPERIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-ACETAMIDOPIPERIDINE(5810-55-9)
• EPA Substance Registry System: 3-ACETAMIDOPIPERIDINE(5810-55-9)

Safety Data

• Hazard Codes: Xn
• Statements: 22
• Safety Statements: 24/25
• HazardClass: IRRITANT
• Hazardous Substances Data: 5810-55-9(Hazardous Substances Data)

Usage

General Description

3-Acetamidopiperidine is an organic chemical compound that is primarily used in the field of pharmaceuticals. The compound has a molecular formula of C7H14N2O and a molecular weight of 142.20 g/mol. It appears as a clear, colourless liquid at room temperature. Its significant pharmaceutical usage comes from it being used as an essential intermediate in the synthesis of a variety of medicinal chemicals, especially in the production of inhibitor drugs. However, it should be handled with appropriate precautions as it can pose potential safety hazards upon exposure.

InChI:InChI=1/C7H14N2O/c1-6(10)9-7-3-2-4-8-5-7/h7-8H,2-5H2,1H3,(H,9,10)

Upstream product

• 462-08-8 pyridin-3-ylamine 
• 129888-60-4 1-(tert-Butoxycarbonyl)-3-(methanesulfonyloxy)piperidine 
• 129888-61-5 3-Azido-1-(tert-butoxycarbonyl)piperidine 
• 85275-45-2 N-tert-butoxycarbonyl-3-piperidinol 
• 6859-99-0 3-hydroxypiperazine 
• 129888-62-6 N-(1-tert-butoxycarbonyl-3-piperidyl)acetamide 
• 5867-45-8 N-(pyridin-3-yl)acetamide 

Downstream Products

• 60407-35-4 1-phenylmethyl-3-aminopiperidine 
• 60169-74-6 3-(N-acetamino)-1-benzylpiperidine 
• 74045-92-4 N'-(1-benzyl-3-piperidinyl)-N-(2-chloroethyl)urea 
• 307532-02-1 3-amino-1-benzylpiperidine dihydrochloride 

Relevant articles and documents

BICYCLIC COMPOUNDS AS INHIBITORS OF PD1/PD-L1 INTERACTION/ACTIVATION

The compounds of Formula I is described herein along with their polymorphs, stereoisomers, tautomers, prodrugs, solvates, and pharmaceutically acceptable salts thereof. The compounds described herein, their polymorphs, stereoisomers, tautomers, prodrugs, solvates, and pharmaceutically acceptable salts thereof are bicyclic compounds that are inhibitors of PD-1/PD-L1 interaction/activation.

Determination of the gauche effect of 3-acetamido- and 3-acetoxy-piperidine and -tetrahydropyran by 1H-n.m.r. spectroscopy

The A-values of the acetamido and the acetoxy group were determined by low-temperature 1H-n.m.r. spectroscopy.The limiting values for the relevant vicinal coupling constants of the newly prepared trans- (22) and cis-5-acetoxy-2-(1-hydroxy-1-methylethyl)tetrahydropyran (24) were obtained at room temperature.The attractive gauche effect of AcNH-3 and AcO-3 in piperidines, piperidinium trifluoroacetates, and tetrahydropyrans was investigated by 1H-n.m.r. spectroscopy both at low temperature (integrals) and at room temperature (band widths and coupling constants).The results obtained at low temperature are more reliable.The position of the conformational equilibrium of N-(3-piperidyl)acetamide (11), N-(1-methyl-3-piperidyl)acetamide (12), and N-(tetrahydropyran-3-yl)acetamide (17) depends strongly upon the nature of the solvent and, in apolar solvents, upon the concentration.