307532-07-6

Usage

Uses

Used in Pharmaceutical Industry:
(S)-2-(DIBENZYLAMINO)-4-METHYL-1-PENTANOL is used as a resolving agent for the synthesis of enantiomerically pure compounds, which is crucial for the development of single-enantiomer drugs that can have fewer side effects and greater efficacy.
Used in Chemical Industry:
(S)-2-(DIBENZYLAMINO)-4-METHYL-1-PENTANOL is used as a chiral auxiliary to assist in asymmetric synthesis, enabling the production of chiral compounds with specific spatial arrangements that are important in various chemical reactions and applications.
Used in Antidepressant Research:
(S)-2-(DIBENZYLAMINO)-4-METHYL-1-PENTANOL is studied for its potential as an antidepressant, given its demonstrated biological activity that could contribute to the development of new treatments for depression.
Used in Anticonvulsant Research:
(S)-2-(DIBENZYLAMINO)-4-METHYL-1-PENTANOL is also being investigated for its potential as an anticonvulsant, with its biological activity suggesting possible use in the management of seizure disorders.

Upstream product

• 691-37-2 4-Methyl-1-pentene 
• 52742-32-2 N,N-dibenzyl-O-benzoylhydroxylamine 
• 7533-40-6 2-amino-4-methyl-1-pentanol 
• 100-39-0 benzyl bromide 

Downstream Products

• 1263198-79-3 (2R)-N,N-dibenzyl-1-ethoxy-4-methylpentan-2-amine 
• 1263198-20-4 tert-butyl (3R,5S)-3-[4-(2-chlorophenyl)-2,2-dimethyl-5-oxopiperazin-1-yl]-5-{[(1R)-1-(ethoxymethyl)-3-methylbutyl]carbamoyl}piperidine-1-carboxylate 
• 1263196-92-4 C₂₆H₄₁ClN₄O₃ 
• 130708-25-7 N,N-dibenzyl-(R)-2-amino-4-methylpentanal 

Relevant academic research and scientific papers

Copper-Catalyzed Regio- and Enantioselective Aminoboration of Unactivated Terminal Alkenes

A CuCl/(R,R)-PTBP-BDPP-catalyzed regioselective and enantioselective aminoboration of simple and unactivated terminal alkenes with bis(pinacolato)diboron (pinB-Bpin) and hydroxylamines has been developed. The amino group and boryl group were incorporated

Synthesis and optimization of novel (3S,5R)-5-(2,2-dimethyl-5-oxo-4- phenylpiperazin-1-yl)piperidine-3-carboxamides as orally active renin inhibitors

We report synthesis and optimization of a series of (3S,5R)-5-(2,2- dimethyl-5-oxo-4-phenylpiperazin-1-yl)piperidine-3-carboxamides as renin inhibitors. Chemical modification of P1, P2 and P 3 portions led to a promising 3

Preparation of aminoalkyl chlorohydrin hydrochlorides: Key building blocks for hydroxyethylamine-based HIV protease inhibitors

Enantiomerically pure N,N-dibenzyl-α-amino aldehydes reacted with (chloromethyl)lithium, generated in situ from bromochloromethane and lithium metal, to give predominantly erythro aminoalkyl epoxides. Treatment of the crude epoxides with aqueous hydrochloric acid gave crystalline (2S,3S)-N,N-dibenzylamino chlorohydrin hydrochlorides in 32-56% overall yield and high isomeric purity. These compounds are versatile synthetic intermediates for the preparation of hydroxyethylamine-based HIV protease inhibitors, either directly as such, or via conversion to the corresponding N-Boc(2S,3S)-aminoalkyl epoxides. The processes described do not make use of hazardous reagents or intermediates, do not require chromatographic purifications, and are thus amenable to the preparation of large quantities of these versatile building blocks.