30779-86-3

Upstream product

• 89622-20-8 3-bromo-3-benzyl-7-methoxychroman-4-one 
• 22141-31-7 4’-methoxy-2’-hydroxyl-dihydrochalcone 
• 109-94-4 formic acid ethyl ester 
• 124-63-0 methanesulfonyl chloride 
• 4637-24-5 N,N-dimethyl-formamide dimethyl acetal 
• 552-41-0 1-(2-hydroxy-4-methoxyphenyl)ethanone 
• 100-39-0 benzyl bromide 
• 462610-98-6 1-(2-((tert-butyldimethylsilyl)oxy)-4-methoxyphenyl)ethan-1-one 
• 462611-06-9 1-[2-(tert-butyl-dimethyl-silanyloxy)-4-methoxy-phenyl]-3-phenyl-propan-1-one 
• 39273-61-5 (E)-1-(2-hydroxy-4-methoxyphenyl)-3-phenylprop-2-en-1-one 
• 76285-73-9 3-benzyl-7-methoxy-4-chromanone 

Relevant academic research and scientific papers

New convenient synthesis of homoisoflavanones and (±)-di-O- methyldihydroeucomin

Upon reaction of 1-(2-hydroxyphenyl)-3-phenylpropane-1-ones (2′-hydroxydihydrochalcones) with dimethylaminodimethoxymethane in boiling toluene, the corresponding 3-benzylchromones are obtained in excellent yields. These latter lead to 3-benzylchroman-4-on

Synthesis and biological evaluation of some novel 4H-benzopyran-4-one derivatives as nonsteroidal antiestrogens

The preparation and characterization of some novel 2- and 3-substituted-7-methoxy-4H-1-benzopyran-4-one are presented. The synthesized compounds were evaluated for their uterotrophic, antiuterotrophic and antiimplantation activities in mature female albino rats. 3-Benzyl-7-methoxy-4H-1-benzopyran-4-one (14) showed the highest uterotrophic activity (87%) based on dry uterine weight gain. The antifertility activity, as assessed by the post-coital antiimplantation activity test, was of weak potency for most compounds (14-29%). Among the products, the 2-(4′-methoxyphenyl)-7-methoxy-4H-1-benzopyran-4-one (19) exhibited the highest antiestrogenic activity of 65%. It also elicited 31% of the uterotrophic activity of estradiol.

Synthesis and angioprotective, antiallergic and antihistaminic activities of 3-benzyl-chromones (homoisoflavones)

Various 3-benzyl-chromones were prepared and their angioprotective antiallergic and antihistaminic activities were studied. - 3-benzyl-chromones / antiallergic / antihistaminic / angioprotective

Homoisoflavones: Part V - Bromination of 3-Benzylchroman-4-ones

Bromination of 3-benzylchroman-4-ones (IIa-e) with cupric bromide or phenyltrimethylammonium perbromide affords the 3-bromo derivatives (IIIa-e) which have been conveniently converted into homoisoflavones (Va-e).) Bromination of IIa-e with N-bromosuccinim