30779-92-1

Upstream product

• 491-37-2 2,3-dihydro-4H-1-benzopyran-4-one 
• 104-87-0 4-methyl-benzaldehyde 
• 533-58-4 2-Iodophenol 
• 96000-21-4 1-(3-chloro-1-propenyl)-4-methylbenzene 
• 1126-20-1 2-allyloxyphenol 
• 108-73-6 3,5-dihydroxyphenol 
• 1224712-75-7 2-[3-(4-methyl phenyl)-prop-2-ynyloxy]-benzaldehyde 
• 108-95-2 phenol 
• 213999-90-7 (E)-2-Phenoxymethyl-3-p-tolyl-acrylic acid methyl ester 
• 139413-76-6 methyl (2Z)-2-(bromomethyl)-3-(4-methylphenyl)prop-2-enoate 
• 213999-96-3 (E)-2-Phenoxymethyl-3-p-tolyl-acrylic acid 

Downstream Products

• 76238-52-3 3-[1-p-Tolyl-meth-(E)-ylidene]-chroman-4-ol 
• 137985-55-8 1-p-Tolyl-1H,10H-9-oxa-2-thia-4-aza-phenanthren-3-ylamine 

Relevant academic research and scientific papers

A Convenient Palladium-Catalyzed Carbonylative Synthesis of (E)-3-Benzylidenechroman-4-ones

A convenient palladium-catalyzed carbonylation reaction for the efficient synthesis of (E)-3-benzylidenechroman-4-ones has been developed. Using TFBen as a solid CO source, a range of substituted (E)-3-benzylidenechroman-4-ones were prepared in moderate to good yields with 2-iodophenols and allyl chlorides as the substrates. Additionally, substituted quinolin-4(1H)-ones can also be obtained with 2-iodoaniline as the starting material.

BF3·OEt2-Mediated Tandem Annulation: A Strategy to Construct Functionalized Chromeno- and Pyrano-Fused Pyridines

A simple and efficient one-pot annulation of arylidenones, alkynes, and nitriles in the presence of BF3·OEt2 is described. A highly functionalized variety of N-substituted pyridine-fused chromeno and pyrano derivatives were obtained

Discovery of 3,3a,4,5-tetrahydro-2H-benzo[g]indazole containing quinoxaline derivatives as novel EGFR/HER-2 dual inhibitors

In the present study, twenty-five pyrazole-quinoxaline derivatives (4a-4y) were designed and synthesized, and their biological activity as potential EGFR or HER-2 kinase inhibitors was evaluated. Among them, compound 4l displayed better antiproliferative

Synthesis, structure, and estrogenic activity of 2- and 3-substituted 2,3-dihydro-4H-1-benzopyran-4-ones

Molecules with potent estrogenic activity are ~270 A3 hydrophobic structures that encompass two hydroxyls among which is at least one phenol. However, compounds with only one phenol or devoid of such a ring have been shown to enhance ERα-mediat

N-heterocyclic carbene-catalyzed cascade reaction involving the hydroacylation of unactivated alkynes

The N-heterocyclic carbene (NHC)-catalyzed hydroacylation of unactivated alkynes to provide α,β-unsaturated ketones is reported. In addition, a rare case of an efficient and selective dually NHC-catalyzed cascade reaction involving the hydroacylation of a

Reactivity of α-arylidene benzoheteracyclanone dibromides toward azide ion: An effective approach to 3-(α-substituted-benzyl)chromones and -1-thiochromones

Treatment of dibromides of 3-arylidenechromanones and -1-thiochromanones with sodium azide resulted in the formation of 3-(α-azidobenzyl)chromones and -1-thiochromones whereas dibromides having no antiperiplanar vicinal hydrogen in the ring such as flavanone, 1-thioflavanone and benzosuberone derivatives afforded only the parent enones by bromine elimination. Evidence supported the intermediacy of 3-(α-bromobenzyl)chromones and -1-thiochromones in this reaction. These postulated intermediates were prepared in an independent way and transformed into azides in high yield.

A new protocol for the syntheses of (E)-3-benzylidenechroman-4-ones: A simple synthesis of the methyl ether of bonducellin

Development of a simple new methodology for the synthesis of (E)-3-benzylidenechroman-4-ones using methyl 3-aryl-3-hydroxy-2-methylenepropanoates, the Baylis-Hillman adducts derived from methyl acrylate, and the application of this methodology for the syn