30818-81-6

Upstream product

• 1431772-07-4 2-(4-methylphenyl)-1,2,3-triazole N-oxide 
• 71-43-2 benzene 
• 1431772-19-8 4-phenyl-2-p-tolyl-2H-1,2,3-triazole N-oxide 
• 539-44-6 N-4-methylphenylhydrazine 
• 70-11-1 α-bromoacetophenone 
• 98-86-2 acetophenone 
• 19433-17-1 acetophenone O-acetyloxime 
• 622-58-2 p-Tolylisocyanate 
• 530-48-3 1,1-Diphenylethylene 
• 613-91-2 acetophenone oxime 
• 75815-82-6 2-(2-(p-tolyl)hydrazono)acetaldehyde 

Relevant academic research and scientific papers

AgNO3as Nitrogen Source for Cu-Catalyzed Cyclization of Oximes with Isocyanates: A Facile Route to N-2-Aryl-1,2,3-triazoles

A versatile copper-catalyzed [3 + 1 + 1] annulation of oximes and isocyanates with AgNO3 is described. In this conversion, AgNO3 and isocyanates instead of conventional azide or diazonium reagents were used as the nitrogen source. This three-component transformation was achieved by cleaving N-O/C-H/C-N bonds and building CN/N-N bonds, which provides a strategy to prepare N-2-aryl-1,2,3-triazoles with a good substrate and functional compatibility.

Another way to the synthesis of 1,2,3-triazoles

The reactions of α-bromoacetophenones with methylhydrazine in refluxing acetic acid generated 2-methyl-4-aryl-2H-[1,2,3]triazoles in good yields. The method was developed by the reactions of α-bromoacetophenones with phenylhydrazines in the presence of cu

Site-selective direct arylation of 1,2,3-triazole N-oxides

An efficient route for the synthesis of 2,4-disubstituted 1,2,3-triazoles by the regioselective direct arylation of 2-aryl-1,2,3-triazole N-oxides with Ar-X [X = Br, I and B(OH)2] is demonstrated. The reaction proceeds through Pd-catalyzed C-H bond activation, and the influence of the aryl halides on the reactivity is investigated. An efficient route for the synthesis of 2,4-disubstituted 1,2,3-triazoles by the regioselective direct arylation of 2-aryl-1,2,3-triazole N-oxides with Ar-X [X = Br, I and B(OH)2] is demonstrated. The reaction proceeds through Pd-catalyzed C-H bond activation, and the influence of the aryl halides on the reactivity is investigated. Copyright

Palladium-catalyzed olefination and arylation of 2-substituted 1,2,3-triazole N -oxides

Two highly efficient protocols for the regioselective synthesis of 2-substituted 4-alkenyl- and 4-aryl-1,2,3-triazoles by the palladium-catalyzed C-H functionalization of 1,2,3-triazole N-oxides are reported. A possible pathway of direct alkenylation with 1-octene and vinyl acetate is discussed.