308276-58-6

Usage

Uses

Used in Pharmaceutical Industry:
1-(2,2-Dimethoxyethyl)-1,6-dihydro-6-oxo-2-phenyl-5-pyrimidinecarboxylic acid methyl ester is used as a potential drug candidate for targeting pyrimidine metabolism, due to its unique chemical structure and the presence of the pyrimidine ring.
Used in Drug Synthesis:
In the pharmaceutical industry, 1-(2,2-Dimethoxyethyl)-1,6-dihydro-6-oxo-2-phenyl-5-pyrimidinecarboxylic acid methyl ester is used as a starting material for the synthesis of other pyrimidine-based compounds, which may have various therapeutic applications.
Used in Research and Development:
Due to its chemical structure and potential biological and pharmacological activities, 1-(2,2-Dimethoxyethyl)-1,6-dihydro-6-oxo-2-phenyl-5-pyrimidinecarboxylic acid methyl ester is used as a subject of interest for further research and development in the fields of medicinal chemistry and drug discovery.

Upstream product

• 308276-57-5 N-(2,2-dimethoxyethyl)benzamidine 
• 100-47-0 benzonitrile 
• 139721-85-0 α-chlorophenylformamidine hydrochloride 

Downstream Products

• 1395047-01-4 1,6-dihydro-1-[2-(methoxyimino)ethyl]-6-oxo-2-phenyl-5-pyrimidinecarboxylic acid methyl ester 
• 1395047-02-5 1,6-dihydro-1-[2-(methoxyimino)ethyl]-6-oxo-2-phenyl-5-pyrimidinecarboxylic acid 
• 1395047-03-6 3-oxo-1-cyclohexen-1-yl 1,6-dihydro-1-[2-(methoxyimino)ethyl]6-oxo-2-phenyl-5-pyrimidinecarboxylate 
• 1395046-66-8 5-[(2-hydroxy-6oxo-1-cyolohexen-1-yl)carbonyl]-6-oxo-2-phenyl-1(6H)-pyrimidineacetaldehyde 1-(O-methyloxime) 
• 293329-60-9 [5-[(benzyloxycarbonyl)amino]-2-phenyl-6-oxo-1,6-dihydro-1-pyrimidinyl]acetaldehyde dimethyl acetal 
• 148745-95-3 2-(5-amino-6-oxo-2-phenyl-1,6-dihydro-1-pyrimidinyl)-N-(3,3,3-trifluoro-1-isopropyl-2-oxopropyl)acetamide 
• 148747-59-5 5-benzyloxycarbonylamino-6-oxo-2-phenyl-1,6-dihydropyrimidin-1-ylmethylcarboxylic acid 
• 148747-58-4 [5-[(benzyloxycarbonyl)amino]-2-phenyl-6-oxo-1,6-dihydro-1-pyrimidinyl]acetaldehyde 
• 154753-60-3 2-(5-benzyloxycarbonylamino-6-oxo-2-phenyl-1,6-dihydro-1-pyrimidinyl)-N-(3,3,3-trifluoro-1-isopropyl-2-oxopropyl)acetamide 
• 293329-57-4 1-(2,2-dimethoxyethyl)-6-oxo-2-phenyl-1,6-dihydropyrimidin-5-ylcarboxylic acid 

Relevant academic research and scientific papers

HERBICIDAL BIS-NITROGEN-CONTAINING OXO HETEROCYCLES

Disclosed are compounds of Formula 1, including all stereoisomers, N oxides, and salts thereof, A is a radical selected from the group consisting of, and B1, B2, B3, T, R1, R2 R3, R4, R5, R6, R7, R8, R9, R10, R11, R12 and R13 are as defined in the disclosure. Also disclosed are compositions containing the compounds of Formula 1 and methods for controlling undesired vegetation comprising contacting the undesired vegetation or its environment with an effective amount of a compound or a composition of the invention.

Nonpeptidic inhibitors of human leukocyte elastase. 5. Design, synthesis, and X-ray crystallography of a series of orally active 5-aminopyrimidin-6- one-containing trifluoromethyl ketones

The effects of changes in substitution in a series of 5-amino-2- pyrimidin-6-ones on both in vitro activity and oral activity in an acute hemorrhage assay have been explored. These compounds contained either a trifluoromethyl ketone or a boronic acid moiety to bind covalently to the Ser-195 hydroxyl of human leukocyte elastase (HLE). Boronic acid-containing inhibitors were found to be more potent than the corresponding trifluoromethyl ketones in vitro but were less active upon oral administration. Compound 13b was found to offer the best combination of oral potency, duration of action, and enzyme selectivity and, as such, was selected for further biological testing. X-ray crystallography of a cocrystallized complex of compound 19m and porcine pancreatic elastase demonstrated that the inhibitor is bound to the enzyme in a manner similar to that found previously for a closely related series of pyridone-containing inhibitors of HLE.