Methyl 1-(2,2-dimethoxyethyl)-6-oxo-2-phenyl-1,6-dihydropyrimidine-5-carboxylate

Base Information

Chemical Name:Methyl 1-(2,2-dimethoxyethyl)-6-oxo-2-phenyl-1,6-dihydropyrimidine-5-carboxylate
CAS No.:308276-58-6
Molecular Formula:C₁₆H₁₈N₂O₅
Molecular Weight:318.329
Hs Code.:
DSSTox Substance ID:DTXSID70438013
Nikkaji Number:J3.047.972F
Wikidata:Q82253618
Mol file:308276-58-6.mol

Synonyms:308276-58-6;METHYL 1-(2,2-DIMETHOXYETHYL)-6-OXO-2-PHENYL-1,6-DIHYDROPYRIMIDINE-5-CARBOXYLATE;SCHEMBL6282014;DTXSID70438013;FT-0736645;1-(2,2-Dimethoxyethyl)-2-phenyl-6-oxo-1,6-dihydropyrimidine-5-carboxylic acid methyl ester

Suppliers and Price of Methyl 1-(2,2-dimethoxyethyl)-6-oxo-2-phenyl-1,6-dihydropyrimidine-5-carboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of Methyl 1-(2,2-dimethoxyethyl)-6-oxo-2-phenyl-1,6-dihydropyrimidine-5-carboxylate

Chemical Property:

XLogP3:1
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:7
Exact Mass:318.12157168
Heavy Atom Count:23
Complexity:505

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:COC(CN1C(=NC=C(C1=O)C(=O)OC)C2=CC=CC=C2)OC

Technology Process of Methyl 1-(2,2-dimethoxyethyl)-6-oxo-2-phenyl-1,6-dihydropyrimidine-5-carboxylate

There total 4 articles about Methyl 1-(2,2-dimethoxyethyl)-6-oxo-2-phenyl-1,6-dihydropyrimidine-5-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 100-47-0
benzonitrile

: 308276-58-6
methyl 1-(2,2-dimethoxyethyl)-1,6-dihydro-6-oxo-2-phenyl-5-pyrimidinecarboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: HCl / ethanol / 16 h / Ambient temperature

2: methanol / 72 h / 5 °C

3: methanol / 1.5 h / 100 °C

With hydrogenchloride; In methanol; ethanol;
DOI:10.1021/jm00001a015

Reference yield:

: 3-methoxymethylene malonate

: 308276-57-5
N-(2,2-dimethoxyethyl)benzamidine

: 308276-58-6
methyl 1-(2,2-dimethoxyethyl)-1,6-dihydro-6-oxo-2-phenyl-5-pyrimidinecarboxylate

Guidance literature:: In methanol; at 100 ℃; for 1.5h;
DOI:10.1021/jm00001a015

Reference yield:

: 139721-85-0
α-chlorophenylformamidine hydrochloride

: 308276-58-6
methyl 1-(2,2-dimethoxyethyl)-1,6-dihydro-6-oxo-2-phenyl-5-pyrimidinecarboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: methanol / 72 h / 5 °C

2: methanol / 1.5 h / 100 °C

In methanol;
DOI:10.1021/jm00001a015