308368-56-1Relevant academic research and scientific papers
Reaction of Benzyl Grignard reagents with trifluoroacetyldihydropyrans and other cyclic β-alkoxy-α,β-unsaturated trifluoromethylketones
Coles, Simon J,Mellor, John M,El-Sagheer, Afaf H,Salem, Ezz El-Din M,Metwally, Reda N
, p. 10057 - 10066 (2000)
Benzyl Grignard reagents react with cyclic β-alkoxy-α,β-unsaturated trifluoromethyl ketones by 1,2-addition to afford unsaturated allylic alcohols in high yield. The factors determining the balance between 1,2- and 1,4-addition to unsaturated ketones are
A synthesis of trifluoromethyl-substituted naphthalenes
Mellor,El-Sagheer,Salem
, p. 7383 - 7386 (2007/10/03)
Alkyl and aryl Grignard reagents add to 1-(3,4-dihydro-2H-5-pyranyl)-2,2,2-trifluoro-1-ethanone by 1,4-addition, but benzyl Grignard reagents react in good yield by 1,2-addition. Dehydration of the resulting alcohols affords intermediate dienes, which readily undergo cyclisation to give substituted trifluoromethyl-naphthalenes. Addition to other trifluoromethylketones permits access to a range of novel fluorinated naphthalenes and benzenes. (C) 2000 Published by Elsevier Science Ltd.
