30837-62-8

Basic information

• Product Name: 1H,3H-PERIMIDINE-2-THIONE
• Synonyms: 1,3-dihydroperimidine-2-thione
• CAS NO: 30837-62-8
• Molecular Formula: C₁₁H₈N₂S
• Molecular Weight: 200.2596
• Mol File: 30837-62-8.mol
• Article Data: 14

Chemical Properties

• Boiling Point: 393.2 °C at 760 mmHg
• Flash Point: 191.6 °C
• Appearance: /
• Density: 1.4 g/cm³
• Vapor Pressure: 2.17E-06mmHg at 25°C
• Refractive Index: 1.81
• CAS DataBase Reference: 1H,3H-PERIMIDINE-2-THIONE(CAS DataBase Reference)
• NIST Chemistry Reference: 1H,3H-PERIMIDINE-2-THIONE(30837-62-8)
• EPA Substance Registry System: 1H,3H-PERIMIDINE-2-THIONE(30837-62-8)

Safety Data

• Hazardous Substances Data: 30837-62-8(Hazardous Substances Data)

Usage

Type of Compound

Heterocyclic compound

Reactivity

Highly reactive

Versatility

Versatile chemical

Applications

a. Organic chemistry
b. Pharmaceuticals
c. Materials science

Usage

Building block for the synthesis of
a. Pharmaceutical intermediates
b. Agrochemicals
c. Dyes

Potential Activity

Antiproliferative and anticancer agent

Research

Studied for potential use in the development of new organic semiconductors for electronic devices

Diverse Reactivity

Ability to participate in a wide range of chemical transformations

Value

Valuable component in the development of novel chemical and pharmaceutical products

InChI:InChI=1/C11H8N2S/c14-11-12-8-5-1-3-7-4-2-6-9(13-11)10(7)8/h1-6H,(H2,12,13,14)

Upstream product

• 1147550-11-5 ammonium thiocyanate 
• 479-27-6 naphthalene-1,8-diamine 
• 103-72-0 phenyl isothiocyanate 
• 75-15-0 carbon disulfide 
• 57-06-7 N-allyl isothiocyanate 
• 140-89-6 potassium ethyl xanthogenate 

Downstream Products

• 41367-13-9 10-isopropyl-9,10-dihydro-thiazolo[3,2-a]perimidin-10-ol 
• 72391-43-6 10,11-dihydro-(9H)-1,3-thiazino<3,2-a>perimidine 
• 5157-11-9 1H,3H-perimidin-2-one 
• 73216-80-5 10-phenylthiazolo[3,2-a]perimidine 
• 1391941-85-7 10-(3-methylphenyl)-8H-1,2,4-triazolo[4,3-a]-perimidine 
• 1391941-86-8 10-(4-methylphenyl)-8H-1,2,4-triazolo[4,3-a]-perimidine 

Relevant articles and documents

Unexpected reaction of 2-hydrazinoperimidine with maleic anhydride: Syntheses of (8-amino-9-oxo-9,10-dihydro-8H-imidazo[1,2-a]perimidin-10-yl)acetic acid and its azomethine derivatives

The reaction of 2-hydrazinoperimidine (3) and maleic anhydride in mild conditions afforded the formation of an unexpected product, namely (8-amino-9-oxo-9,10-dihydro-8H-imidazo[1,2-a]perimidin-10-yl)acetic acid (5). The possible mechanism of this reaction

New divalent metal ion complexes with 1,8-diaminonapthalene-2-thione: Synthesis, Spectroscopic, anti-bacterial and anticancer activity studies

Treatment of two molar equivalents of 1,8-diaminonaphthalene-2-thione with one molar equivalent of the metal's(II) salt (Pd, Pt, Hg, Cd, Zn) afforded both neutral thione complexes and thionate derived complexes. The prepared ligand and its complexes (1-8) were characterized via different spectroscopic technics including: FT-IR, 1H, 13C-NMR, and mass spectroscopy. The spectroscopic data analysis suggested that these compounds adopt different structural geometries. For instance, Pd(II) and Pt(II) complexes show square planar geometry. Whereas, thione complexes of Hg(II), Zn(II), and Cd(II) showed probable tetrahedral structure. However, thionate derived complexes of Hg, and Ph-Hg are expected to be linear. The thionato-Cd(II) complex show bidentate chelating mode through its N and S donor atoms. Furthermore, the newly prepared complexes exhibit nano-structural characteristics, which were measured by SEM and X-Ray diffraction of the powder. SEM data showed that complexes from (3, 5) and (8) gave irregular nano-structure, nano-rod structure, and nano-sphere structural pattern respectively. On the other hand, Complexes (1) and (2) were tested against MCF-7 (breast) and LoVo (colon) cancer cells using MTT assay. It was found that the palladium complex showed a promising antiproliferative activity against colon (LoVo) and breast (MCF-7) cancer cells with IC50 values 21.13 and 22.25 μM respectively. In addition the anti-bacterial activity was study against two different pathogenic bacteria, and the Pd(II) complex displayed highest activity compared with other complexes.

Synthesis and anorectic effects of some fused perimidine derivatives

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A Highly Efficient Synthesis of 2-Benzimidazolthiones and Their Congeners under Mild Conditions

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Fragment based search for small molecule inhibitors of HIV-1 Tat-TAR

Basic molecular building blocks such as benzene rings, amidines, guanidines, and amino groups have been combined in a systematic way to generate ligand candidates for HIV-1 TAR RNA. Ranking of the resulting compounds was achieved in a fluorimetric Tat-TAR