30858-79-8Relevant academic research and scientific papers
Highly Efficient Mechanochemical N-Arylation of Amino Alcohols and Diamines with Cu0 Powder
Martina, Katia,Rinaldi, Laura,Baricco, Francesca,Boffa, Luisa,Cravotto, Giancarlo
, p. 2789 - 2794 (2015/12/18)
Cu0-catalysed arylations have rightly acquired great importance over the last decade. This paper reports the N-arylation of amino alcohols and diamines with iodobenzene derivatives in a planetary ball mill and an investigation into the procedure. This newly developed solvent-free protocol is fast, efficient and occurs under the mechanochemical activation of metallic copper powder. It does not require additional ligands and gives excellent yields. This paper aims to broaden the scope of mechanochemical Cu0-activation and so a new one-pot, two-step synthesis that combines CuAAC and N-arylation has been successfully performed and reported herein.
Cyclizations via enamine intermediates with amine dehydrogenations
M?hrle,Mehrens
, p. 214 - 224 (2007/10/03)
The mercury-edta dehydrogenation of the 4'-aminosubstituted-acetophenones 1, 8a and 9a produced the ring cleavaged derivatives 7, 11a and 12a, while the piperidine and its derivatives 10a - 10e gave rise to tetracyclic compounds 16a - 16e and to methylenedi-enamines 19a - 19d, the additionally C-1-fragment in 19a - 19d probably coming from mercury edta. With addition of m-nitrobenzaldehyde to the mercury-edta dehydrogenation of substituted phenylpiperidines another route only generated the di-enamines 22.
