309267-51-4Relevant academic research and scientific papers
Mechanochemical synthesis of ethyl 4-(3-aryl-1-phenyl-1H-pyrazol-4- yl)-6-methyl-2-oxo/thioxo-1,2,3,4-tetrahydro-pyrimidine-5- carboxylates and their antimicrobial activity
Sarasija,Ashok,Sudershan,Shivaraj
, p. 349 - 352 (2019/01/21)
An efficient and greener approach has been described for the synthesis of ethyl 4- (3-aryl-1-phenyl-1H-pyrazol-4-yl)-6-methyl-2-oxo/thioxo-1,2,3,4-tetrahydropyrimidine-5- carboxylates by multicomponent reaction of 3-aryl-1-phenyl-1H-pyrazole-4- carboxalde
Synthesis and in vitro anticancer and antitubercular activity of diarylpyrazole ligated dihydropyrimidines possessing lipophilic carbamoyl group
Yadlapalli, Rama Krishna,Chourasia,Vemuri, Kiranmayi,Sritharan, Manjula,Perali, Ramu Sridhar
, p. 2708 - 2711 (2012/05/20)
A series of dihydropyrimidine derivatives were synthesized by utilizing Biginelli reaction and evaluated for their in vitro anticancer activity against MCF-7 human breast cancer (HBC) cell line using sulforhodamine B (SRB) assay and antitubercular activity against Mycobacterium tuberculosis (MTB) H 37Rv using Microplate Alamar Blue Assay (MABA). Compounds 13p, 13t were exhibited 70.6% and 63.7% of HBC cell growth inhibition at 10 μM concentration. Interestingly compound 13p was also found to be the most potent in the series against MTB H37Rv with MIC value of 0.125 μg/mL.
Novel dihydropyrimidines as a potential new class of antitubercular agents
Trivedi, Amit R.,Bhuva, Vimal R.,Dholariya, Bipin H.,Dodiya, Dipti K.,Kataria, Vipul B.,Shah, Viresh H.
supporting information; experimental part, p. 6100 - 6102 (2010/11/18)
A small library of 30 dihydropyrimidines was synthesized and evaluated for their in vitro antitubercular activity against Mycobacterium tuberculosis H 37Rv. Two compounds, ethyl 4-[3-(4-fluorophenyl)-1-phenyl-1H-pyrazol- 4-yl]-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5 carboxylate 4a and ethyl 4-[3-(4-nitrophenyl)-1-phenyl-1H-pyrazol-4-yl]-6-methyl-2-oxo-1,2,3, 4-tetrahydropyrimidine-5-carboxylate 4d were found to be the most active compounds in vitro with MIC of 0.02 μg/mL against MTB and were more potent than isoniazid.
4-Functionally substituted 3-heterylpyrazoles: XIII. 3-Aryl(heteryl)-4-(4- pyrazolyl)-1,2,3,4-tetrahydropyrimidin-2-ones(thiones)
Bratenko,Chornous,Vovk
, p. 95 - 97 (2007/10/03)
Cyclocondesation of 3-aryl(heteryl)pyrazole-4-carbaldehydes with ethyl acetoacetate and urea (thiourea) in the presence of FeCl3· 6H2O afforded 3-aryl(heteryl)-4-(4-pyrazolyl)-1,2,3,4- tetrahydropyrimidin-2-ones(thiones). 2005 Pleiad
