30932-41-3Relevant articles and documents
Nickel-Catalyzed Favorskii-Type Rearrangement of Cyclobutanone Oxime Esters to Cyclopropanecarbonitriles
Fang, Ping,Mei, Tian-Sheng,Shuai, Bin
supporting information, p. 1637 - 1641 (2021/10/02)
A nickel-catalyzed base-promoted rearrangement of cyclobutanone oxime esters to cyclopropanecarbonitriles was developed. The ring opening of cyclobutanone oxime esters occurs at the sterically less hindered side. A base-promoted nickelacyclobutane intermediate, formed in situ, is assumed to be involved in the formation of the product.
Preparation method of cibenzoline succinate midbody
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Paragraph 0015; 0016; 0017; 0018, (2017/12/09)
The invention discloses a preparation method of a cibenzoline succinate midbody, relates to a preparation method of the cibenzoline succinate midbody 1-cyanogroup-2,2-diphenyl cyclopropane and belongs to the field of drug chemical synthesis. The preparation method comprises the following steps that an oxidation reaction is generated with benzophenone hydrazone as a raw material and hydrogen peroxide as an oxidizing agent under the presence of a phase transfer catalyst, then diphenyldiazomethane is obtained and directly reacts with acrylonitrile without purification in the reaction system, and the midbody 1-cyanogroup-2,2-diphenyl cyclopropane is obtained. According to the method, the recovery rate is high, operation is easy and convenient, discharging of three wastes is reduced, the production cost of cibenzoline succinate is reduced remarkably, and the method is quite beneficial for industrialized production.
Novel process for the synthesis of class I antiarrhythmic agent (±)-cibenzoline and its analogs
Gholap, Atul R.,Paul, Vincent,Srinivasan, Kumar V.
, p. 2967 - 2982 (2008/12/22)
Synthesis of (±)-cibenzoline and its analogs has been achieved by a simple sequence of reactions. The diaryl cyanoolefin intermediate 3 could be prepared by Knoevenagel condensation of benzophenone with ethylcyanoacetate to form the tetra-substituted olefin intermediate 2 followed by Krapcho deethoxycarbonylation or from β-hydroxynitrile intermediate 2' followed by the elimination of hydroxyl group respectively. The 2,2- diphenylcyclopropanecarbonitrile 4 was synthesized from intermediate 3 by cyclopropanation, which was converted to (±)-2-(2,2-diphenylcyclopropyl)- 2-imidazoline 5 by reaction with ethylenediamine in the presence of a catalytic amount of sulfur. Moreover, the obtained 2-imidazolines were smoothly oxidized to the corresponding imidazoles 6 in good to moderate yields. Copyright Taylor & Francis Group, LLC.
