30935-15-0Relevant academic research and scientific papers
Pyrrole Annulation onto Aldehydes and Ketones via Palladium-Catalyzed Reactions
Trost, Barry M.,Keinan, Ehud
, p. 2741 - 2746 (2007/10/02)
α-Dicarbonyl systems reacted with vinylmagnesium bromide and acetic anhydride to give α-acetoxy-α-vinylalkanones.These substrates react with benzylamine in the presence of tetrakis(triphenylphosphine)palladium to give N-benzylpyrroles with substituents in the two and/or three position.The functiodifferentiated synthesis of α-dicarbonyl compounds from ketones makes this a pyrrole annulation onto any α-methylene carbonyl system.
