30953-83-4

Upstream product

• 712-50-5 Cyclohexyl phenyl ketone 
• 114531-89-4 (S)-(-)-3-cyclohexyl-3-hydroxy-3-phenylpropanoic acid 
• 114499-81-9 (S)-(+)-1-cyclohexyl-1-phenyl-1,3-propanediol 
• 123-75-1 pyrrolidine 
• 114499-82-0 (S)-(-)-3-chloro-1-cyclohexyl-1-phenyl-1-propanol 

Relevant academic research and scientific papers

Syntheses of (S)-(+)-trihexyphenidyl hydrochloride and (S)-(+)-procyclidine hydrochloride, two anticholinergics, using (S)-(-)-3-cyclohexyl-3-hydroxy-3-phenylpropanoic acid as chiral synthon.

The absolute configuration of the more active (-)-enantiomer of the anticholinergic trihexyphenidyl hydrochloride has been established as (R) by syntheses of (S)-(+)-procyclidine hydrochloride, whose absolute configuration has been established previously,