309757-64-0

Upstream product

• 14990-09-1 tert-butyl cinnamate 
• 120343-46-6 (S)-N-benzyl-N-(α-methyl-p-methoxybenzyl)amine 
• 6298-96-0 (S)-1-(4-methoxyphenyl)ethylamine 
• 160460-40-2 [(S)-1-(4-Methoxy-phenyl)-ethyl]-[1-phenyl-meth-(E)-ylidene]-amine 
• 100-52-7 benzaldehyde 

Downstream Products

• 309757-65-1 (3R,αS)-tert-Butyl 3-(N-α-methyl-4-methoxybenzylamino)-3-phenyl propanoate 
• 161671-34-7 tert-butyl (R)-3-amino-3-phenylpropionate 
• 67321-63-5 (R)-N-benzyl-β³-homophenylglycine 
• 37088-65-6 (3R)-4-phenyl-2-azetidinone 
• 19340-71-7 (R)-1-benzyl-4-phenylazetidin-2-one 
• 614-19-7 (R)-3-phenyl-3-aminopropionic acid 
• 445018-42-8 (4R,αS)-N-(α-methyl-4-methoxybenzy)-4-phenylazetidin-2-one 
• 445018-41-7 (3R,αS)-3-(N-α-methyl-4-methoxybenzylamino)-3-phenylpropionic acid 

Relevant academic research and scientific papers

Orthogonal N,N-deprotection strategies of β-amino esters

β-Amino esters derived from the stereoselective conjugate addition of homochiral lithium N-benzyl-N-α-methyl-4-methoxybenzylamide to α,β-unsaturated esters may be orthogonally mono-N-deprotected under either oxidative or acid-promoted reaction conditions. Further oxidative deprotection affordsβ-amino acids or β-lactams.

The asymmetric synthesis of β-haloaryl-β-amino acid derivatives

Lithium N-benzyl-N-α-methyl-4-methoxybenzylamide is employed as a homochiral ammonia equivalent for the asymmetric synthesis of β-haloaryl-β-amino acid derivatives using a conjugate addition/oxidative deprotection strategy.