309762-67-2

Upstream product

• 309762-64-9 2-Benzyl 4-Ethyl 4,8,8-Trimethyl-6,10-dioxa-2-azaspiro[4.5]decane-2,4-dicarboxylate 
• 309762-63-8 1-benzyloxycarbonyl-3-methyl-4-oxopyrrolidine-3-carboxylic acid ethyl ester 
• 309762-65-0 ethyl 4,8,8-Trimethyl-6,10-dioxa-2-azaspiro[4.5]decane-4-carboxylate 
• 51814-19-8 1-Benzyloxycarbonyl-4-ethoxycarbonyl-3-oxopyrrolidine 
• 309762-66-1 ethyl 2-Benzyl-4,8,8-trimethyl-6,10-dioxa-2-azaspiro[4.5]decane-4-carboxylate 

Downstream Products

• 309762-68-3 2-Benzyl-4-methanesulfonyloxymethyl-4,8,8-trimethyl-6,10-dioxa-2-azaspiro[4.5]decane 
• 309762-71-8 2-benzyl-4-aminomethyl-4,8,8-trimethyl-6,10-dioxa-2-azaspiro[4.5]decane 
• 683251-63-0 C-(2-benzyl-4,8,8-trimethyl-6,10-dioxa-2-aza-spiro[4.5]dec-4-yl)-methylamine 
• 683251-66-3 C-(2-benzyl-4,8,8-trimethyl-6,10-dioxa-2-aza-spiro[4.5]dec-4-yl)-methylamine 
• 309762-69-4 2-Benzyl-4-azidomethyl-4,8,8-trimethyl-6,10-dioxa-2-azaspiro[4.5]decane 
• 682801-80-5 (2-benzyl-4,8,8-trimethyl-6,10-dioxa-2-aza-spiro[4.5]dec-4-ylmethyl)-carbamic acid tert-butyl ester 
• 682802-03-5 (S)-1-(Toluene-4-sulfonyl)-pyrrolidine-2-carboxylic acid ((R)-2-benzyl-4,8,8-trimethyl-6,10-dioxa-2-aza-spiro[4.5]dec-4-ylmethyl)-amide 
• 682802-01-3 (S)-1-(Toluene-4-sulfonyl)-pyrrolidine-2-carboxylic acid ((S)-2-benzyl-4,8,8-trimethyl-6,10-dioxa-2-aza-spiro[4.5]dec-4-ylmethyl)-amide 

Relevant academic research and scientific papers

Syntheses and biological evaluation of new fluoroquinolone antibacterials containing chiral oxiimino pyrrolidine

The design and syntheses of new fluoroquinolone antibacterial agents having pyrrolidine ring at C-7 position are described. The pyrrolidine ring is optically active and possesses methyloxime functional group. Two of them have excellent in vitro antibacterial activities and pharmacokinetic profiles.

Optically active quinoline carboxylic acid derivatives with 7-pyrrolidine substituents causing optical activity and a process for the preparation thereof

The present invention relates to optically active quinoline carboxylic acid derivatives, their pharmaceutically acceptable salts, their solvates, and a process for the preparation thereof. More specifically, the present invention relates to optically active quinoline carboxylic acid derivatives containing 4-aminomethyl-4-methyl-3-(Z)-alkoxyirninopyrrolidine substituents causing optical activity at the 7-position of the quinolone nuclei. As the compounds of the present invention have superior antibacterial activity and pharmacokinetic profiles to their enantiomers, their racemates and conventional antibacterial agents, with nearly no phototoxicity, the compounds of this invention are useful for antibacterial agents.