30984-53-3

Basic information

• Product Name: 3-(3-FLUOROPHENYL)-1-PROPENE
• Synonyms: 3-(3-FLUOROPHENYL)-1-PROPENE
• CAS NO: 30984-53-3
• Molecular Formula: C₉H₉F
• Molecular Weight: 136.17
• Mol File: 30984-53-3.mol
• Article Data: 8

Chemical Properties

• Boiling Point: 45°C 5mm
• Flash Point: 39°C
• Appearance: /
• Density: 0.986g/cm³
• Vapor Pressure: 3.67mmHg at 25°C
• Refractive Index: 1.493
• CAS DataBase Reference: 3-(3-FLUOROPHENYL)-1-PROPENE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(3-FLUOROPHENYL)-1-PROPENE(30984-53-3)
• EPA Substance Registry System: 3-(3-FLUOROPHENYL)-1-PROPENE(30984-53-3)

Safety Data

• Statements: 36/37/38
• Safety Statements: 26-36/37/39
• Hazardous Substances Data: 30984-53-3(Hazardous Substances Data)

Usage

InChI:InChI=1/C9H9F/c1-2-4-8-5-3-6-9(10)7-8/h2-3,5-7H,1,4H2

Upstream product

• 372-19-0 meta-fluoroaniline 
• 1981-80-2 allyl radical 
• 1073-06-9 3-fluorobromobenzene 
• 17318-03-5 bromo(3-fluorophenyl)magnesium 
• 106-95-6 allyl bromide 
• 1996-38-9 3-fluorobenzenediazonium tetrafluoroborate 
• 84680-82-0 C₁₇H₁₄ClFO₄ 

Downstream Products

• 1737-19-5 (3-fluorophenyl)acetone 
• 1626-71-7 (±)-1-(3-fluorophenyl)propan-2-amine 
• 455-67-4 1-(3-fluorophenyl)propan-1-one 

Relevant articles and documents

Markovnikov Wacker-Tsuji Oxidation of Allyl(hetero)arenes and Application in a One-Pot Photo-Metal-Biocatalytic Approach to Enantioenriched Amines and Alcohols

The Wacker-Tsuji aerobic oxidation of various allyl(hetero)arenes under photocatalytic conditions to form the corresponding methyl ketones is presented. By using a palladium complex [PdCl2(MeCN)2] and the photosensitizer [Acr-Mes]ClO4 in aqueous medium and at room temperature, and by simple irradiation with blue led light, the desired carbonyl compounds were synthesized with high conversions (>80%) and excellent selectivities (>90%). The key process was the transient formation of Pd nanoparticles that can activate oxygen, thus recycling the Pd(II) species necessary in the Wacker oxidative reaction. While light irradiation was strictly mandatory, the addition of the photocatalyst improved the reaction selectivity, due to the formation of the starting allyl(hetero)arene from some of the obtained by-products, thus entering back in the Wacker-Tsuji catalytic cycle. Once optimized, the oxidation reaction was combined in a one-pot two-step sequential protocol with an enzymatic transformation. Depending on the biocatalyst employed, i. e. an amine transaminase or an alcohol dehydrogenase, the corresponding (R)- and (S)-1-arylpropan-2-amines or 1-arylpropan-2-ols, respectively, could be synthesized in most cases with high yields (>70%) and in enantiopure form. Finally, an application of this photo-metal-biocatalytic strategy has been demonstrated in order to get access in a straightforward manner to selegiline, an anti-Parkinson drug. (Figure presented.).

Palladium-catalyzed oxidative allylation of bis[(pinacolato)boryl]methane: Synthesis of homoallylic boronic esters

A palladium-catalyzed oxidative allylation of bis[(pinacolato)boryl]methane to afford the corresponding homoallylic organoboronic esters with moderate to excellent yields is reported. This novel transformation provides an efficient strategy for the construction of homoallylic organoboronic esters in one step with a broad substrate scope. It is proposed that the palladium-catalyzed oxidative allylic C-H bond activation process may be involved in the catalytic cycle.

Cascade multicomponent synthesis of indoles, pyrazoles, and pyridazinones by functionalization of alkenes

The development of multicomponent reactions for indole synthesis is demanding and has hardly been explored. The present study describes the development of a novel multicomponent, cascade approach for indole synthesis. Various substituted indole derivative