31009-33-3 Usage
Uses
Used in Pharmaceutical Industry:
4-BROMO-6-FLUORO-2-(TRIFLUOROMETHYL)QUINOLINE is used as an intermediate in the synthesis of various biologically active compounds, including potential drug candidates. Its unique structure and functional groups make it a valuable component in the development of new pharmaceuticals.
Used in Medicinal Chemistry:
4-BROMO-6-FLUORO-2-(TRIFLUOROMETHYL)QUINOLINE is used as a building block for the design and synthesis of novel compounds with enhanced biological activity. The presence of the trifluoromethyl group can improve the potency, selectivity, and metabolic stability of the resulting molecules, making them more effective as therapeutic agents.
Used in Chemical Research:
4-BROMO-6-FLUORO-2-(TRIFLUOROMETHYL)QUINOLINE is utilized in chemical research to explore the effects of its structural features on the properties and reactivity of quinoline derivatives. This knowledge can be applied to the development of new synthetic methods and the discovery of new compounds with potential applications in various fields.
Used in Material Science:
The unique combination of bromine and fluorine atoms in 4-BROMO-6-FLUORO-2-(TRIFLUOROMETHYL)QUINOLINE may offer interesting properties for material science applications, such as the development of new materials with specific electronic, optical, or magnetic properties. Further research in this area could lead to the discovery of novel materials with potential uses in various industries.
Check Digit Verification of cas no
The CAS Registry Mumber 31009-33-3 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 3,1,0,0 and 9 respectively; the second part has 2 digits, 3 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 31009-33:
(7*3)+(6*1)+(5*0)+(4*0)+(3*9)+(2*3)+(1*3)=63
63 % 10 = 3
So 31009-33-3 is a valid CAS Registry Number.
InChI:InChI=1/C10H4BrF4N/c11-7-4-9(10(13,14)15)16-8-2-1-5(12)3-6(7)8/h1-4H
31009-33-3Relevant academic research and scientific papers
Selective and efficient structural elaboration of 2-(trifluoromethyl)quinolinones
Marull, Marc,Schlosser, Manfred
, p. 1576 - 1588 (2007/10/03)
The acid-catalyzed cyclization-condensation between anilines and ethyl 4,4,4-trifluoroacetoacetate affords 1,4-dihydro-2-trifluoromethyl-4H-4-quinolinones (1), which can easily be converted into 4-bromo-2-(trifluoromethyl)quinolines. These undergo halogen/metal exchange, generating 2-trifluoromethyl-4-quinolyllithiums, when treated with butyllithium, and hydrogen/metal exchange, generating 4-bromo-2-trifluoromethyl-3-quinolyllithiums, when treated with lithium diisopropylamide. Trapping of the latter intermediates provides 3-functionalized products that may be further elaborated by electrophilic substitution of the bromine atom. A few unexpected findings resulted from these investigations, the most noteworthy being an unprecedented buttressing effect and a counterintuitive halogen reactivity. ( Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2003).
