31009-33-3 Usage
General Description
4-Bromo-6-fluoro-2-(trifluoromethyl)quinoline is a chemical compound with a molecular formula C10H5BrF4N. It is a quinoline derivative with a bromine atom at the 4-position and a fluorine atom at the 6-position, as well as a trifluoromethyl group attached to the 2-position. 4-BROMO-6-FLUORO-2-(TRIFLUOROMETHYL)QUINOLINE is commonly used in the pharmaceutical industry as an intermediate for the synthesis of various biologically active compounds, including potential drug candidates. Its trifluoromethyl group makes it a valuable building block for medicinal chemistry, as the presence of trifluoromethyl groups in organic molecules can enhance their biological activity and metabolic stability. Additionally, the combination of bromine and fluorine in the structure gives this compound potentially useful properties for a range of applications in different industries.
Check Digit Verification of cas no
The CAS Registry Mumber 31009-33-3 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 3,1,0,0 and 9 respectively; the second part has 2 digits, 3 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 31009-33:
(7*3)+(6*1)+(5*0)+(4*0)+(3*9)+(2*3)+(1*3)=63
63 % 10 = 3
So 31009-33-3 is a valid CAS Registry Number.
InChI:InChI=1/C10H4BrF4N/c11-7-4-9(10(13,14)15)16-8-2-1-5(12)3-6(7)8/h1-4H
31009-33-3Relevant articles and documents
Selective and efficient structural elaboration of 2-(trifluoromethyl)quinolinones
Marull, Marc,Schlosser, Manfred
, p. 1576 - 1588 (2007/10/03)
The acid-catalyzed cyclization-condensation between anilines and ethyl 4,4,4-trifluoroacetoacetate affords 1,4-dihydro-2-trifluoromethyl-4H-4-quinolinones (1), which can easily be converted into 4-bromo-2-(trifluoromethyl)quinolines. These undergo halogen/metal exchange, generating 2-trifluoromethyl-4-quinolyllithiums, when treated with butyllithium, and hydrogen/metal exchange, generating 4-bromo-2-trifluoromethyl-3-quinolyllithiums, when treated with lithium diisopropylamide. Trapping of the latter intermediates provides 3-functionalized products that may be further elaborated by electrophilic substitution of the bromine atom. A few unexpected findings resulted from these investigations, the most noteworthy being an unprecedented buttressing effect and a counterintuitive halogen reactivity. ( Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2003).
