310455-01-7Relevant academic research and scientific papers
Asymmetric Hydrogenation of 3-Substituted Pyridinium Salts
Renom-Carrasco, Marc,Gajewski, Piotr,Pignataro, Luca,de Vries, Johannes G.,Piarulli, Umberto,Gennari, Cesare,Lefort, Laurent
, p. 9528 - 9532 (2016)
The use of an equivalent amount of an organic base leads to high enantiomeric excess in the asymmetric hydrogenation of N-benzylated 3-substituted pyridinium salts into the corresponding piperidines. Indeed, in the presence of Et3N, a Rh-JosiPhos catalyst reduced a range of pyridinium salts with ee values up to 90 %. The role of the base was elucidated with a mechanistic study involving the isolation of the various reaction intermediates and isotopic labeling experiments. Additionally, this study provided some evidence for an enantiodetermining step involving a dihydropyridine intermediate.
Immunopotentiator agents
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Page column 23, (2010/02/05)
Novel compounds and methods for preparing same, immunopotentiating compositions, and a method for potentiating the immune system of a host animal. The method comprises administering to the animal an effective amount of an immunopotentiating compound of Formula I or Formula II, or a physiologically acceptable salt.
