310466-38-7

Usage

Uses

Used in Pharmaceutical Industry:
Benzo[b]thiophene, 4-fluoro(9CI) is used as a key intermediate in the synthesis of various pharmaceuticals for its potential anti-inflammatory, anti-cancer, and antifungal properties. Its derivatives have shown promising results in modulating biological pathways and targeting specific diseases.
Used in Agrochemical Industry:
In the agrochemical industry, Benzo[b]thiophene, 4-fluoro(9CI) is utilized as a building block for the development of novel agrochemicals, such as pesticides and herbicides, to enhance crop protection and yield.
Used in Dyes and Pigments Production:
Benzo[b]thiophene, 4-fluoro(9CI) is employed in the production of dyes and pigments due to its unique chemical structure and properties, contributing to the creation of a wide range of colorants for various applications.
However, it is important to note that the potential hazards and health effects of Benzo[b]thiophene, 4-fluoro(9CI) on humans and the environment have not been fully studied and understood. Therefore, it is crucial to handle this chemical with care and adhere to safety protocols when working with it to minimize any potential risks.

InChI:InChI=1/C8H5FS/c9-7-2-1-3-8-6(7)4-5-10-8/h1-5H

Upstream product

• 1263280-02-9 ethyl 4-fluorobenzo[b]thiophene-2-carboxylate 
• 96-45-7 N,N'-ethylenethiourea 
• 360575-20-8 2-chloro-1-(4-fluorobenzo[b]thiophen-2-yl)ethan-1-one 
• 220180-55-2 methyl 4-fluorobenzo[b]thiophene-2-carboxylate 
• 310466-37-6 4-fluoro-1-benzothiophene-2-carboxylic acid 
• 501944-64-5 3-fluorobenzenethioacetaldehyde diethyl acetal 
• 437-81-0 2,6-difluorobenzaldehyde 

Downstream Products

• 34577-05-4 benzo[b]thiophen-4-yl benzoate 

Relevant academic research and scientific papers

Design and development of cyclometalated ruthenium complexes containing thiophenyl-pyridine ligand for dye-sensitized solar cells

Two new cyclometalated ruthenium sensitizers NC102 (1) and NC103 (2), where the two NCS- ligands of the N3 analog were replaced with the 2-thiophen-2-yl-pyridine and 2-benzo[b]thiophen-2-yl-pyridine ligands, respectively, were designed and synthesized for dye-sensitized solar cell applications. The effects of these two ligands on the photophysical behavior of ruthenium complexes were investigated by their optical, electrochemical, and photovoltaic properties. The sensitizer NC103 (2) with the fluoride substitution in the ligand exhibited the best cell performance with a short-circuit current (Jsc) of 9.45 mA/cm2, an open-circuit voltage (V oc) of 630 mV, and a fill factor (FF) of 0.71, giving an overall power conversion efficiency of (η) 4.22% under simulated AM 1.5 irradiation.

Indole derivatives for the treatment of depression and anxiety

The present invention provides compounds of formula (I): which are useful for treating depression, anxiety, and alleviating the symptoms caused by withdrawal or partial withdrawal from the use of tobacco or of nicotine.

C17,20-lyase inhibitors I. Structure-based de novo design and SAR study of C17,20-lyase inhibitors.

Novel nonsteroidal C(17,20)-lyase inhibitors were synthesized using de novo design based on its substrate, 17 alpha-hydroxypregnenolone, and several compounds exhibited potent C(17,20)-lyase inhibition. However, in vivo activities were found to be short-lasting, and in order to improve the duration of action, a series of benzothiophene derivatives were evaluated. As a result, compounds 9h, (S)-9i, and 9k with nanomolar enzyme inhibition (IC(50)=4-9 nM) and 9e (IC(50)=27 nM) were identified to have powerful in vivo efficacy with extended duration of action. The key structural determinants for the in vivo efficacy were demonstrated to be the 5-fluoro group on the benzothiophene ring and the 4-imidazolyl moiety. Superimposition of 9k and 17 alpha-hydroxypregnenolone demonstrated their structural similarity and enabled rationalization of the pharmacological results. In addition, selected compounds were also identified to be potent inhibitors of human enzyme with IC(50) values of 20-30 nM.

An improved synthesis of substituted benzo[b]thiophenes using microwave irradiation

An easy and high-yielding method for the synthesis of substituted benzo[b]thiophenes using microwave irradiation is described.

Dihydroimidazo[2,1-b]thiazole and dihydro-5h-thiazolo[3,2-A]pyrimidines as antidepressant agents

The present invention relates to certain novel substituted dihydroimidazo[2,1-b]thiazole and dihydro-5H-thiazolo[3,2-a]pyrimidine compounds of Formula (I) including pharmaceutically acceptable salts thereof in which have affinity for 5-HT1A receptors and which inhibits neuronal reuptake of 5-hydroxytryptamine and/or noradrenaline, to processes for their preparation, to pharmaceutical compositions containing them and to their use in the treatment of depression, anxiety, psychoses (for example schizophrenia), tardive dyskinesia, obesity, drug addiction, drug abuse, cognitive disorders, Alzheimer's disease, obsessive-compulsive behaviour, panic attacks, social phobias, eating disorders such as bulimia, anorexia, snacking and binge eating, non-insulin dependent diabetes mellitus, hyperglycaemia, hyperlipidaemia, stress, as an aid to smoking cessation and in the treatment and/or prophylaxis of seizures, neurological disorders such as epilepsy and/or in which there is neurological damage such as stroke, brain trauma, cerebral ischaemia, head injuries and haemorrhage.