31084-54-5

Basic information

• Product Name: Benzenamine, 3-methoxy-N-propyl-
• Synonyms: N-Propyl-maleinamidsaeure;N-propyl-3-methoxyaniline;N-n-Propyl-maleinsaeuremonoamid;N-n-Propyl-m-methoxyanilin;Maleinsaeure-mono-propylamid;N-propyl-malamic acid;N-propyl-m-anisidine;N-n-Propylmaleamidic acid;N-Propyl maleamic acid;N-Propyl-m-anisidin;Maleinsaeuremono-n-propylamid;(Z)-4-Oxo-4-(propylamino)-2-butenoic acid;4-oxo-4-(propylamino)isocrotonic acid
• CAS NO: 31084-54-5
• Molecular Formula: C10H15NO
• Molecular Weight: 165.235
• Mol File: 31084-54-5.mol
• Article Data: 7

Chemical Properties

• CAS DataBase Reference: Benzenamine, 3-methoxy-N-propyl-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzenamine, 3-methoxy-N-propyl-(31084-54-5)
• EPA Substance Registry System: Benzenamine, 3-methoxy-N-propyl-(31084-54-5)

Safety Data

• Hazardous Substances Data: 31084-54-5(Hazardous Substances Data)

Upstream product

• 536-90-3 m-Anisidine 
• 107-08-4 1-iodo-propane 
• 106-94-5 propyl bromide 
• 588-16-9 m-methoxyacetanilide 
• 107-12-0 propiononitrile 
• 107-10-8 propylamine 
• 2398-37-0 3-methoxyphenyl bromide 
• 555-03-3 3-nitroanisole 
• 123-38-6 propionaldehyde 
• 3739-64-8 allyl n-butyl ether 

Downstream Products

• 1130681-84-3 2-acetoxy-N-(3-methoxyphenyl)-N-propylacetamide 
• 64062-54-0 3-(2-Methoxy-aethoxycarbonyl-amino)-phenyl-N-propyl-N-methoxy-carbanilat 

Relevant articles and documents

Development and radiosynthesis of the first 18F-labeled inhibitor of monocarboxylate transporters (MCTs)

Monocarboxylate transporters 1 and 4 (MCT1 and MCT4) are involved in tumor development and progression. Their expression levels are related to clinical disease prognosis. Accordingly, both MCTs are promising drug targets for treatment of a variety of human cancers. The noninvasive imaging of these MCTs in cancers is regarded to be advantageous for assessing MCT-mediated effects on chemotherapy and radiosensitization using specific MCT inhibitors. Herein, we describe a method for the radiosynthesis of [18F]FACH ((E)-2-cyano-3-{4-[(3-[18F]fluoropropyl)(propyl)amino]-2-methoxyphenyl}acrylic acid), as a novel radiolabeled MCT1/4 inhibitor for imaging with PET. A fluorinated analog of α-cyano-4-hydroxycinnamic acid (FACH) was synthesized, and the inhibition of MCT1 and MCT4 was measured via an L-[14C]lactate uptake assay. Radiolabeling was performed by a two-step protocol comprising the radiosynthesis of the intermediate (E)/(Z)-[18F]tert-Bu-FACH (tert-butyl (E)/(Z)-2-cyano-3-{4-[(3-[18F]fluoropropyl)(propyl)amino]-2-methoxyphenyl}acrylate) followed by deprotection of the tert-butyl group. The radiofluorination was successfully implemented using either K[18F]F-K2.2.2-carbonate or [18F]TBAF. The final deprotected product [18F]FACH was only obtained when [18F]tert-Bu-FACH was formed by the latter procedure. After optimization of the deprotection reaction, [18F]FACH was obtained in high radiochemical yields (39.6?±?8.3%, end of bombardment (EOB) and radiochemical purity (greater than 98%).

Assembly of substituted 2-alkylquinolines by a sequential palladium-catalyzed Ci-N and Ci-C bond formation

Diversity: A range of substituted 2-alkylquinolines can be prepared in a general and efficient synthetic approach that employs mild reaction conditions (see scheme). The synthesis is based on a sequential palladium-catalyzed Ci-N and Ci-C bond formation, followed by palladium-catalyzed aromatization, and results in the formation of the desired compounds in one step. Copyright

One-pot reductive monoalkylation of nitro aryls with hydrogen over Pd/C

A range of different nitro aryls were converted in one-pot to the corresponding secondary alkyl amino aryls in good to excellent yields by using aldehydes as alkyl source and hydrogen over Pd/C (10%) as reducing agent. In all examples, but one, the second