31090-77-4

Usage

Uses

Used in Pharmaceutical Industry:
1-(2-aminoethyl)-3-phenylthiourea is used as a potential anti-cancer agent for its demonstrated biological activities against cancer cells. It is being researched for its ability to inhibit tumor growth and its potential synergistic effects when combined with conventional chemotherapeutic drugs.
Used in Microbiology:
1-(2-aminoethyl)-3-phenylthiourea is used as an antimicrobial agent for its ability to inhibit the growth of certain microorganisms, making it a candidate for development in the field of infectious disease treatment.
Used in Neurological Disorders Treatment:
1-(2-aminoethyl)-3-phenylthiourea is used as a potential therapeutic agent for neurological disorders due to its investigational use in treating such conditions. Further research is needed to understand its full potential and mechanism of action in this application.

InChI:InChI=1/C9H13N3S/c10-6-7-11-9(13)12-8-4-2-1-3-5-8/h1-5H,6-7,10H2,(H2,11,12,13)

Upstream product

• 24775-54-0 1,1'-(ethane-1,2-diyl)bis(3-phenylthiourea) 
• 103-72-0 phenyl isothiocyanate 
• 107-15-3 ethylenediamine 

Downstream Products

• 1270151-47-7 IR-897 
• 1848-75-5 2-(phenylimino)-imidazolidine 
• 123557-18-6 <7-(2-formamido-ethyl)-3-(2-acetamido-ethyl)>-3,3'-bis-phenyl-thiourea-N¹⁰-phenethylisoalloxazine 
• 1848-75-5 N-phenyl-N-(4,5-dihydro-1H-imidazol-2-yl)amine 
• 96-45-7 N,N'-ethylenethiourea 
• 62-53-3 aniline 
• 65417-30-3 N-phenyl-N'-[2-(N'-phenyl-thioureido)-ethyl]-urea 

Relevant academic research and scientific papers

A cyanine-modified nanosystem for in vivo upconversion luminescence bioimaging of methylmercury

Methylmercury (MeHg+) is a strong liposoluble ion, which can be accumulated in the organs of animals and can cause prenatal nervous system and visceral damage. Therefore, the efficient and sensitive monitoring of MeHg + in organisms is of great importance. Upconversion luminescence (UCL) detection based on rare-earth upconversion nanophosphors (UCNPs) as probes has been proved to exhibit a large anti-Stokes shift, no autofluorescence from biological samples, a remarkably deep penetration depth, and no photobleaching. In this study, a hydrophobic heptamethine cyanine dye (hCy7) modified by two long alkyl moieties and amphiphilic polymer (P-PEG)-modified nanophosphors (hCy7-UCNPs) was fabricated as a highly sensitive water-soluble probe for UCL monitoring and bioimaging of MeHg+. Further application of hCy7-UCNPs for sensing MeHg+ was confirmed by an optical titration experiment and upconversion luminescence live cell imaging. Using the ratiometric upconversion luminescence as a detection signal, which provides a built-in correction for environmental effects, the detection limit of MeHg+ for this nanosystem was as low as 0.18 ppb. Importantly, the hCy7-UCNPs nanosystem was shown to be capable of monitoring MeHg+ex vivo and in vivo by upconversion luminescence bioimaging.

Bisthiourea: Thermal and structural investigation

Bisthiourea derivatives 1,1′-(ethane-1,2-diyl)bis(3-phenylthiourea), 1,1′-(propane-1,3-diyl)bis(3-phenylthiourea), and 1,1′-(butane-1,4- diyl)bis(3-phenylthiourea) have been synthesized and characterized by IR, 1H NMR, and 13C NMR. Suitable crystals of 1,1′-(propane-1,3-diyl)bis(3-phenylthiourea) were grown for single-crystal X-ray analysis and from the data it was observed that they organize into the P-1 space group. The thermal decomposition of these compounds has been studied by TG-DSC.

Near-infrared cell-permeable Hg2+-selective ratiometric fluorescent chemodosimeters and fast indicator paper for MeHG+ based on tricarbocyanines

Three tricarbocyanine dyes (IR-897, IR-877, and IR-925) with different thiourea substituents that function as dosimeter units through specific Hg 2+-induced desulfurization have been demonstrated in a fast indicator paper for Hg2+ an

Novel anion receptors based on thiacalix[4]arene derivatives

Starting from the thiacalix[4]arene tetraacetate, novel derivatives bearing four ureido or thioureido functions on the lower rim have been prepared. As proven by NMR titrations, these compounds can bind anions via hydrogen bonding interactions and represent the first example of anion receptors in the thiacalixarene series. The thiacalix[4]arene-tetraacetates or diacetates (cone) serve as a starting point for novel thiacalixarenes derivatives bearing urea or thiourea units on the lower rim. As revealed by NMR titration experiments, these compounds are preorganised for anion recognition in organic solvents.

Process for synthesizing heterocyclic compounds

The invention provides the process illustrated in scheme 1 for synthesizing heterocyclic compounds of formula I. In the process, an isothiocyanate of formula II is initially reacted with a primary amine of formula III to give a thiourea of formula IV. Subsequently, the thiourea of formula IV is converted to the corresponding heterocycle of formula I using a base and a sulfonyl chloride.

1-aryloxy-3-(substituted aminoalkylamino)-2-propanols

1-Aryloxy-3-(substituted aminoalkylamino)-2-propanols and pharmaceutically acceptable salts thereof have β-adrenergic blocking activity with some cardioselectivity and hence are useful as antihypertensive, antianginal, antiarrhythmic and cardioprotective

Antihypertensive (2-Aminoethyl)thiourea Derivatives. 1

Structure-activity studies were carried out on a series of antihypertensive 1-(2-aminoethyl)-3-(substituted phenyl)thioureas.From this class of compounds, the 2,6-dichlorophenyl analogue 2 was found to have potent oral antihypertensive activity in two hypertensive rat models and the renal hypertensive dog.In addition to its effect on blood pressure, 2 displayed sedative effects which had a marked species specificity.