31101-37-8Relevant academic research and scientific papers
Traceless solid-phase synthesis of 2-amino-5-alkylidene-thiazol-4-ones
Pulici, Maurizio,Quartieri, Francesca
, p. 2387 - 2391 (2007/10/03)
2-Amino-5-alkylidene-thiazol-4-ones bearing two diversity points are prepared by a solid-phase strategy exploiting rhodanine as the starting material. Rhodanine is first loaded on bromo-Wang resin, subjected to Knovenagel condensation with aldehydes, and cleaved off the resin in a traceless manner by means of an amine.
2-Dialkylamino-thiazolin-4-ones from α-Thiocyanato-carboxylic Acid Derivatives
Zimmermann, T.,Fischer, G. W.,Olk, B.
, p. 540 - 546 (2007/10/02)
α-Thiocyanato-acetic acid esters 1 a-c or amide 1 d react with dialkylamine salts of weak acids to give 2-dialkylamino-thiazolin-4-ones 2 a-f.The reaction can be performed using aliphatic alcohols, dipolar aprotic solvents or halogenated hydrocarbons as reaction medium or by heating the educts at 90 deg C without any solvent.According to the latter method, the 5-substituted thiazolinones 2 g, h are obtained from α-thiocyanatopropionic acid ethyl ester (1 d) or α-thiocyanato-phenylacetic acid ethyl ester (1 e) and dimethylamine actetate. - I.r., u.v. and n.m.r. data of the thiazolinones 2 are reported.
