4540-33-4

Usage

Chemical Properties

white solid

InChI:InChI=1/C5H11N.C2H4O2/c1-2-4-6-5-3-1;1-2(3)4/h6H,1-5H2;1H3,(H,3,4)

Upstream product

• 107-91-5 cyanoacetic acid amide 
• 1122-98-1 1-cyclopentyl-propan-2-one 
• 109-94-4 formic acid ethyl ester 
• 5586-88-9 1-(4-chlorophenyl)propan-2-one 
• 41894-93-3 hexahydro-indan-2-one 
• 6975-60-6 1-furan-2-yl-propan-2-one 
• 206666-54-8 [2-(4,5-Dimethyl-2-piperidin-1-yl-[1,3]dithiol-2-yl)-benzo[1,3]dithiol-2-yl]-phosphonic acid diethyl ester 
• 110-89-4 piperidine 
• 64-19-7 acetic acid 

Downstream Products

• 72046-73-2 1,1'-Methylenebis(2,4,6-trimethoxybenzene) 
• 79512-87-1 11t-(4-methoxy-phenyl)-undeca-2t,4t,6t,8t,10-pentaenal 
• 28790-87-6 ethyl 1,2-dimethyl-4-oxocyclohex-2-ene-1-carboxylate 
• 80466-34-8 2,4-hexadienal 
• 17609-31-3 2,4,6-octatrienal 
• 40650-87-1 2,4,6,8-decatetraenal 
• 779-90-8 1,3,5-triacetylbenzene 
• 10519-33-2 dec-3-en-2-one 
• 51407-83-1 5,5-dimethyl-2-(N-piperidinomethyl)-3-anilino-2-cyclohexen-1-one 
• 23071-56-9 1-(4-Dimethylaminophenylimino-)-2-keto-2-(4-tolyl)-propionitril 
• 125488-17-7 4-(2,4-Dichlor-phenyl)-2-piperidino-thiazol 
• 93595-16-5 1-(N-morpholino)-5-(N-piperidino)-2,4-diphenylpentan-3-one 
• 125488-16-6 4-(4-bromophenyl)-2-(piperidin-1-yl)thiazole 
• 60998-25-6 pentadeca-2,4-dienal 

Relevant academic research and scientific papers

Regioselective one-pot synthesis and anti-proliferative and apoptotic effects of some novel tetrazolo[1,5-a]pyrimidine derivatives

An easy and efficient route for the synthesis of some tetrazolo[1,5-a]-pyrimidine derivatives was described through the reaction of sodium salts of formyl cycloalkanones with 5-aminotetrazole monohydrate. The derivative 6,7,8,9-tetrahydrotetrazolo[1,5-a]quinazoline (6b) has profound anti-tumor cytotoxic effects against Ehrlich ascites carcinoma (EAC) both in vivo and in vitro and against hepatocellular carcinoma (HepG2) cell line in vitro. These anti-tumor effects may be mediated via stimulation of cell cycle arrest and apoptosis through down-regulation of Bcl-2 and up-regulation of p53 transcription factors.

Chemoselective γ-Oxidation of β,γ-Unsaturated Amides with TEMPO

A chemoselective and robust protocol for the γ-oxidation of β,γ-unsaturated amides is reported. In this method, electrophilic amide activation, in a rare application to unsaturated amides, enables a regioselective reaction with TEMPO resulting in the title products. Radical cyclisation reactions and oxidation of the synthesised products highlight the synthetic utility of the products obtained.

Impact of an aryl bulky group on a one-pot reaction of aldehyde with malononitrile and: N-substituted 2-cyanoacetamide

In this study, we successfully explored the effect of steric hindrance on the one-pot reaction of different aryl aldehydes with malononitrile and N-substituted 2-cyanoacetamide in the presence of piperidinium acetate as the catalyst. It involved the Knoevenagel condensation of the aldehyde and malononitrile to produce arylidene malononitrile as an intermediate, which was further treated with N-substituted 2-cyanoacetamide to give 6-Amino-2-pyridone-3,5-dicarbonitrile derivatives when the less steric bulky group was involved. High steric hindrance changed the earlier reaction route and gave N-substituted 2-cyanoacrylamides via a slower route.

Morpholinium trifluoroacetate-catalyzed aldol condensation of acetone with both aromatic and aliphatic aldehydes

We report a highly efficient, general and practical method for the aldol condensation of acetone with aromatic and aliphatic aldehydes, using morpholinium trifluoroacetate as a catalyst.

MACROCYCLIC LACTONES AS FRAGRANCES

The present invention refers to methyl-substituted double-unsaturated macrocyclic lactones comprising 14 to 17 ring atoms of formula (I) wherein n and m are independently selected from 1, 2, 3 and 4 with the proviso that 3 ≤ n + m ≤ 6. The invention relates furthermore to their use as odorant and fragrance composition comprising them.

ANTI-VIRAL COMPOUNDS

Compounds effective in inhibiting replication of Hepatitis C virus ("HCV") or other viruses are disclosed. This invention is also directed to compositions comprising such compounds, co-formulation or co-administration of such compounds with other anti-viral or therapeutic agents, processes and intermediates for the syntheses of such compounds, and methods of using such compounds for the treatment of HCV or other viral infections.

COMPOUNDS FOR INHIBITING KSP KINESIN ACTIVITY

The present invention provides compounds of Formula (I) (wherein R1, R3, X, W, Z and ring Y are as defined herein). The present invention also provides compositions comprising these compounds that are useful for treating cellular proliferative diseases or disorders associated with KSP kinesin activity and for inhibiting KSP kinesin activity.

TRICYCLIC FUROPYRIDINE DERIVATIVES USEFUL IN THE TREATMENT OF HYPER-PROLIFERATIVE DISORDERS

This invention relates to a compound of Formula (I) Wherein X is CH2, 0 or N(C1-C3)alkyl; Ar1 is phenyl or pyridyl each optionally substituted with 1 or 2 substituents selected from (C1-C3)alkoxy, halo, OH, CF3, CN, NO2 and(C1-C3)alkyl, said alkyl being optionally substituted with CF3; or a pharmaceutically acceptable salt thereof, and its use in treating hyper-proliferative disorders.

FUROPYRIDINE AND FUROPYRIMIDINE DERIVATIVES FOR THE TREATMENT OF HYPER-PROLIFERATIVE DISORDERS

This invention relates to a compound of Formula (I) wherein Y is CH or N; Ar1is phenyl or pyridyl each optionally substituted with 1 or 2 substituents each selected independently from (C1-C3)alkoxy halo, OH, CF3, CN, NO2 and (C1-C3)alkyl, said alkyl being optionally substituted with CF3; Ar2 is phenyl or pyridyl each optionally substituted with 1 or 2 substituents each independently selected from halo, OH, CN, NO2, CF3, (C1-C6)alkoxy, NR1R1, S(O)2R2, C(O)R3, and (C1-C6)alkyl optionally substituted with R4, and its use in treating hyper-proliferative disorders.

Methods and compositions for determining the sequence of nucleic acid molecules

Methods and compounds, including compositions therefrom, are provided for determining the sequence of nucleic acid molecules. The methods permit the determination of multiple nucleic acid sequences simultaneously. The compounds are used as tags to generate tagged nucleic acid fragments which are complementary to a selected target nucleic acid molecule. Each tag is correlative with a particular nucleotide and, in a preferred embodiment, is detectable by mass spectrometry. Following separation of the tagged fragments by sequential length, the tags are cleaved from the tagged fragments. In a preferred embodiment, the tags are detected by mass spectrometry and the sequence of the nucleic acid molecule is determined therefrom. The individual steps of the methods can be used in automated format, e.g., by the incorporation into systems.