31107-20-7

Usage

Uses

Used in Organic Synthesis:
2-methyl-2-nitroso-propane is used as a reagent for the nitrosation of organic compounds, serving as a source of the nitrosonium cation. This application is crucial for the synthesis of various organic compounds.
Used in Pharmaceutical Production:
2-methyl-2-nitroso-propane is utilized in the production of pharmaceuticals, playing a significant role in the development of new drugs and medicines.
Used in the Synthesis of Nitrosamines:
2-methyl-2-nitroso-propane is also used in the synthesis of nitrosamines, which, despite being known carcinogens, have specific applications in research and certain industrial processes.
Used as a Solvent:
In chemical research and various industrial applications, 2-methyl-2-nitroso-propane serves as a solvent, facilitating reactions and processes that require a suitable liquid medium.
Used in Chemical Research:
2-methyl-2-nitroso-propane is employed in chemical research to study the properties and reactions of nitroso compounds, contributing to the advancement of organic chemistry and related fields.

Upstream product

• 75-64-9 tert-butylamine 
• 118891-54-6 methyl N-(1,1-dimethylethyl)benzenecarboximidate N-oxide 

Downstream Products

• 402588-66-3 bis[4-(N-hydroxy-tert-butylamino)phenyl]dimethylsilane 
• 402588-64-1 1,2-bis[4-(N-hydroxy-tert-butylamino)phenyl]-1,1,2,2-tetramethyldisilane 
• 402588-72-1 1,2-bis[3-(N-hydroxy-tert-butylamino)phenyl]-1,1,2,2-tetramethyldisilane 
• 402588-77-6 bis[3-(N-hydroxy-tert-butylamino)phenyl]dimethylsilane 
• 402588-75-4 [3-(N-hydroxy-tert-butylamino)phenyl][4-(N-hydroxy-tert-butylamino)phenyl]dimethylsilane 
• 402588-70-9 1-[3-(N-hydroxy-tert-butylamino)phenyl]-2-[4-(N-hydroxy-tert-butylamino)phenyl]-1,1,2,2-tetramethyldisilane 

Relevant academic research and scientific papers

Action d'un Tetrafluoroborate d'Oxaziridinium sur les Amines et les Imines

The Oxaziridinium salt 1 derived from dihydroisoquinolin is an oxygen transfer reagent to primary amines leading to nitrosoderivatives (if R = Alkyl) or nitro compounds (if R = Aryl), to tertiary amines leading to N-oxides, and to secondary amines and imines leading to the corresponding nitrone.

α-Heteroatom-Substituted Nitrones. Synthesis and Reactions of Acyclic α-Alkoxynitrones

A general method was developed for the synthesis of acyclic α-alkoxynitrones (imidate N-oxides), a relatively new class of compounds.Regioselective alkylation of hydroxamic acids under neutral conditions with alkyl trifluoromethanesulfonates (triflates) gave nitrone hydrotriflates, and deprotonation by one of three methods gave the rather unstable nitrones in overall yields from 4 to 85percent.A wide range of substitution was possible, with R = H, Me, or Ar, R1 = Me or t-Bu, and R2 = Me or Et.The reactivity of these nitrones toward examples of various classes of reagents was investigated.Nitrone 3e (R = H, R1 = t-Bu, R2 = Me), the most reactive one studied, gave the following results: (1) with nucleophiles (aniline, n-butylamine, thiophenol, n-butyl mercaptan, and potassium cyanide), substitution of the α-OMe group produced new nitrones with amino, thio, and cyano groups in the α position; (2) with a reducing agent (NaBH4), N-tert-butylnitrone was formed; (3) with an oxidizing agent (m-chloroperbenzoic acid), oxidation and cleavage gave methyl formate and 2-methyl-2-nitrosopropane monomer and dimer; (4) with an electrophilic acylating agent (p-nitrobenzoyl chloride), methyl p-nitrobenzoate, N,O-bis(p-nitrobenzoyl)-N-tert-butylhydroxylamine, and N-tert-butyl-O-(p-nitrobenzoyl)hydroxylamine were produced.In parallel with the similar reactivity of aldo- and ketonitrones to ketones, the present α-alkoxynitrones undergo reactions analogous to those of esters with nucleophilic-type reagents.