3112-74-1Relevant articles and documents
Production and Characterization of a New Copper(II) Propanoate-Isonicotinamide Adduct Obtained via Slow Evaporation and using Supercritical CO2 as an Antisolvent
Cuadra, Isaac A.,Martínez-Casado, Francisco J.,Cheda, José A. R.,Redondo,Pando, Concepción,Cabanas, Albertina
, p. 620 - 629 (2019/02/14)
A new adduct of isonicotinamide (INA) with copper(II) propanoate [Cu(C3)2] was prepared [Cu2(C3)4(INA)4] using two different methods. This type of compound shows high fungicidal activity. Solvent evaporation from ethanol rendered crystals suitable for single-crystal X-ray diffraction. Furthermore, a new semicontinuous method capable of simultaneous crystallization and micronization of the adduct using supercritical CO2, the supercritical antisolvent technique (SAS), was also assessed. Crystals were characterized using powder X-ray diffraction, infrared spectroscopy, differential scanning calorimetry, thermogravimetric analysis coupled with mass spectrometry, scanning electron microscopy, and microelemental analysis. In the adduct, two copper(II) ions are coordinated through two bridging and two chelating carboxylates to the propanoate anions forming approximately a plane. Each metal ion is then coordinated with the pyridine nitrogen of two different INA molecules that behave as monodentate ligands. The amide groups of the INA form H-bonds with other amide and carboxylate groups forming a molecular crystal with a three-dimensional H-bond arrangement of the binuclear units. With the SAS technique, crystals 100-fold smaller than those obtained by slow evaporation were obtained, proving SAS as a suitable method for mixed-ligand complexes preparation with reduced particle size and therefore expected bioavailability enhancement.
Dual C-H activations of electron-deficient heteroarenes: Palladium-catalyzed oxidative cross coupling of thiazoles with azine N-oxides
Fu, Xiao-Pu,Xuan, Qing-Qing,Liu, Li,Wang, Dong,Chen, Yong-Jun,Li, Chao-Jun
, p. 4436 - 4444 (2013/06/26)
The palladium-catalyzed, copper-promoted cross-dehydrogenative-coupling (CDC) of electron-deficient thiazoles with azine N-oxides through dual C-H activations was developed. It was found that copper(II) pivalate was an efficient dual-function reagent for the oxidative cross-coupling reactions, playing the roles of both an oxidant and a C-H bond activation promoter. This methodology provides a simple way to construct 2-thiazolyl pyridine moiety.
One-dimensional and two-dimensional coordination polymers from self-assembling of trinuclear triangular cu(II) secondary building units
Casarin, Maurizio,Corvaja, Carlo,Di Nicola, Corrado,Falcomer, Daniele,Franco, Lorenzo,Monari, Magda,Pandolfo, Luciano,Pettinari, Claudio,Piccinelli, Fabio
, p. 6265 - 6276 (2008/10/09)
The reactions of pyrazole (Hpz) with some copper(II) carboxylates in the presence of water yield trinuclear copper derivatives characterized by the triangular core [Cu3(μ3-OH)(μ-pz) 3(RCOO)2] (R = H, C2H5, C 3H7). Copper(II) formate gives [Cu3(μ 3-OH)(μ-pz)3(HCOO)2(Hpz)2] (1), whereas copper propionate and butyrate afford [Cu3(μ3- OH)(μ-pz)3-(C2H5COO)2(EtOH)] (2) and [Cu3(μ3-OH)(μ-pz)3(C 3H7COO)2(MeOH)(H2O)] (3), respectively, both containing solvent molecules coordinated to copper atoms. Magnetic susceptibilities are consistent with a single unpaired electron for each trinuclear unit of 1-3, and EPR measurements indicate that higher spin states, generated by exchange coupling between copper atoms, may be populated at room temperature. Density-functional calculations provide the description of the electronic structures of 1-3, allowing, at the same time, the assignment of their UV-vis absorption spectra. X-ray molecular structure determinations show that triangular trinuclear units of 1 are connected to each other through single formate bridges, forming one-dimensional (1D) zigzag coordination polymers, whereas in 2 and 3, two oxygen atoms of two carboxylate ions doubly bridge two copper atoms of different triangles, thus generating hexanuclear units. Moreover, in 2, two other propionate ions link together two hexanuclear units yielding a 12-membered cycle and giving rise to 1D coordination polymers. The supramolecular assemblies of 1-3 are compared to that of the previously reported trinuclear triangular copper(II) derivative [Cu3(μ3- OH)(μ-pz)3(CH3COO)2-(Hpz)] (A), where a two-dimensional (2D) coordination polymer is present. The reactions of 3,5-dimethylpyrazole (Hpz*) with copper(II) carboxylates in the same conditions yield 1:2 Cu(RCOO)2/Hpz* adducts.
