31144-31-7

Upstream product

• 112949-17-4 1,2-bis-phenylethynyl-cyclohexane-1,2-diol 
• 13146-23-1 copper(I) phenylacetylenide 
• 114493-71-9 1,2-diiodocyclohex-1-ene 
• 77267-31-3 1,10-diphenyl-1,9-decadiyne-3,8-dione 
• 834918-88-6 cyclohexene-1,2-diyl bis(trifluoromethanesulfonate) 
• 536-74-3 phenylacetylene 
• 591-50-4 iodobenzene 
• 303142-40-7 1-(1-ethynyl)-2-(2-phenyl-1-ethynyl)-1-cyclohexene 
• 904743-82-4 N¹,N⁶-dimethoxy-N¹,N⁶-dimethyladipamide 
• 871927-57-0 1,10-diphenyl-1,9-decadiyne-3,8-diol 
• 501-65-5 diphenyl acetylene 
• 90-43-7 2-Phenylphenol 
• 111-50-2 Adipic acid dichloride 
• 21403-38-3 2-(phenylacetylenyl)cyclohex-1-enecarbaldehyde 

Downstream Products

• 30266-46-7 2,3-Diphenyl-8-phenylethynyl-1-(2-phenylethynyl-cyclohex-1-enyl)-4,5,6,7-tetrahydro-azulene 
• 56598-71-1 6,7-Diphenyl-1,2,3,4-tetrahydronaphthalene 
• 31144-50-0 1,2-Diphenyl-4-phenylethynyl-3-(2-phenylethynyl-cyclohex-1-enyl)-azulene 
• 30266-48-9 1,2-Diphenyl-3-(2-phenylethenyl-cyclohexen-⁽¹⁾-yl)-4-phenylethenyl-azulen 

Relevant academic research and scientific papers

Gold-catalyzed intramolecular [3 + 2]-cycloaddition of arenyne-yne functionalities

We report a new efficient intramolecular [3 + 2]-cycloaddition of unactivated arenyne (or enyne)-yne functionalities, catalyzed mainly by the AuPPh3SbF6 complex (2 mol %) under ambient conditions. The value of this cyclization is ref

Synthesis and protein degradation capacity of photoactivated enediynes

The viability of proteins as targets of thermally and photoactivated enediynes has been confirmed at the molecular level. Model studies using a labeled substrate confirmed the efficacy of atom transfer from diyl radicals produced from enediynes to form captodatively stabilized carbon centered aminoacyl radicals, which then undergo either fragmentation or dimerization. To exploit this finding, a family of enediynes was developed using an intramolecular coupling strategy. Derivatives were prepared and used to target specific proteins, showing good correlation between affinity and photoinduced protein degrading activity. The findings have potential applications in the design of artificial chemical proteases and add to our understanding of the mechanism of action of the clinically important enediyne antitumor antibiotics.

Fancy bioisosteres: Synthesis and dopaminergic properties of the endiyne FAUC 88 as a novel non-aromatic D3 agonist

Enlargement of the π-electronic system of the non-aromatic D3 agonist FAUC 73 led to dopaminergic endiynes of type 1 being synthesized via the bromovinyl triflate 7a as a key intermediate when palladium catalyzed coupling reactions were exploited for the

Formation of enediynes by reductive coupling followed by alkyne metathesis

One aspect of the present invention relates to methods of preparing enedialkylidyne complexes, enediynes, and alkyne metathesis catalysts, as well as methods of catalyzing alkyne metathesis reactions. The present invention also relates to methods of activating enedialkylidyne complexes for metathesis. The present invention also relates to enedialkylidyne complexes.

Polar Effects in the Transition State of the Bergman Cyclization

From the kinetic data of enediynes 1a-c it is concluded that electron withdrawing substituents are lowering the free activation energy in the Bergman cycloaromatization by decreasing the repulsion of the in-plane ?-orbitals.