303142-40-7

Upstream product

• 303142-39-4 triisopropyl-2-[2-(2-phenyl-1-ethynyl)-1-cyclohexenyl]-1-ethynylsilane 
• 437608-26-9 2-ethynyl-1-phenylethynyl-cyclohexanol 
• 911708-72-0 [2-(2,2-dibromo-vinyl)-cyclohex-1-enylethynyl]-benzene 
• 21403-38-3 2-(phenylacetylenyl)cyclohex-1-enecarbaldehyde 
• 38127-47-8 2-bromocyclohex-1-ene-1-carbaldehyde 
• 108-94-1 cyclohexanone 
• 303142-38-3 (3,8-dibromo-10-phenyl-1,9-decadiynyl)(triisopropyl)silane 
• 303142-37-2 1-phenyl-10-(1,1,1-triisopropylsilyl)-1,9-decadiyne-3,8-diol 

Downstream Products

• 399566-75-7 tert-butyl-dimethyl-[3-(2-phenylethynyl-cyclohex-1-enylethynyl)-phenylethynyl]-silane 
• 71313-45-6 3-(cyclohex-1-enyl)prop-2-yn-1-ol 
• 521334-59-8 6-(3-{[2-(phenylethynyl)-1-cyclohexenyl]ethynyl}phenyl)hexanoic acid 
• 303142-45-2 (2S)-3-phenyl-2-[6-(3-(2-[2-(2-phenyl-1-ethynyl)-1-cyclohexenyl]-1-ethynyl)-phenyl)-5-hexynoyl]aminopropanoic acid 
• 303142-44-1 methyl(2S)-3-phenyl-2-[6-(3-(2-[2-(2-phenyl-1-ethynyl)-1-cyclohexenyl]-1-ethynyl)-phenyl)-5-hexynoyl]aminopropanoate 
• 303142-43-0 6-(3-(2-[2-(2-phenyl-1-ethynyl)-1-cyclohexenyl]-1-ethynyl)-phenyl)-5-hexynoic acid 
• 871927-92-3 2-[3-benzyloxycarbonyl-2-(3-benzyloxycarbonyl-2-{6-[3-(2-phenylethynyl-cyclohex-1-enylethynyl)-phenyl]-hex-5-ynoylamino}-propionylamino)propionylamino]-succinic acid dimethyl ester 
• 871927-93-4 1-(phenylethynyl)-2-((3-ethynylphenyl)ethynyl)cyclohexene 
• 911708-47-9 [3-(3-cyclohex-1-enyl-prop-2-ynyloxy)-prop-1-ynyl]-benzene 
• 31144-31-7 (cyclohexene-1,2-diyl-bisethynyl)-bisbenzene 
• 871927-80-9 methyl 6-(3-(2-[2-(2-phenyl-1-ethynyl)-1-cyclohexenyl]-1-ethynyl)-phenyl)-5-hexynoate 

Relevant academic research and scientific papers

Gold-catalyzed intramolecular [3 + 2]-cycloaddition of arenyne-yne functionalities

We report a new efficient intramolecular [3 + 2]-cycloaddition of unactivated arenyne (or enyne)-yne functionalities, catalyzed mainly by the AuPPh3SbF6 complex (2 mol %) under ambient conditions. The value of this cyclization is ref

Synthesis and protein degradation capacity of photoactivated enediynes

The viability of proteins as targets of thermally and photoactivated enediynes has been confirmed at the molecular level. Model studies using a labeled substrate confirmed the efficacy of atom transfer from diyl radicals produced from enediynes to form captodatively stabilized carbon centered aminoacyl radicals, which then undergo either fragmentation or dimerization. To exploit this finding, a family of enediynes was developed using an intramolecular coupling strategy. Derivatives were prepared and used to target specific proteins, showing good correlation between affinity and photoinduced protein degrading activity. The findings have potential applications in the design of artificial chemical proteases and add to our understanding of the mechanism of action of the clinically important enediyne antitumor antibiotics.

Novel chemistry of α-tosyloxy ketones: Applications to the solution- and solid-phase synthesis of privileged heterocycle and enediyne libraries

New synthetic technologies for the preparation and elaboration of α-tosyloxy ketones in solution and on solid-phase are described. Both olefins and ketones serve as precursors to these relatively stable chemical entities: olefins via a novel one-pot epoxi