311767-75-6

Basic information

• Product Name: 3-cyano-5-oxo-4-(2-thienyl)-indeno[1,2-b]pyridin-2[1H]-thione
• Synonyms: 3-cyano-5-oxo-4-(2-thienyl)-indeno[1,2-b]pyridin-2[1H]-thione
• CAS NO: 311767-75-6
• Molecular Weight: 320.395
• Mol File: 311767-75-6.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 3-cyano-5-oxo-4-(2-thienyl)-indeno[1,2-b]pyridin-2[1H]-thione(CAS DataBase Reference)
• NIST Chemistry Reference: 3-cyano-5-oxo-4-(2-thienyl)-indeno[1,2-b]pyridin-2[1H]-thione(311767-75-6)
• EPA Substance Registry System: 3-cyano-5-oxo-4-(2-thienyl)-indeno[1,2-b]pyridin-2[1H]-thione(311767-75-6)

Safety Data

• Hazardous Substances Data: 311767-75-6(Hazardous Substances Data)

Upstream product

• 7357-70-2 Cyanothioacetamide 
• 24760-36-9 2-(thiophen-2-ylmethylene)indan-1,3-dione 

Downstream Products

• 952720-96-6 C₂₅H₁₄ClN₃O₂S₂ 
• 952720-99-9 C₂₆H₁₇N₃O₃S₂ 
• 952720-97-7 C₂₅H₁₄N₂O₂S₂ 

Relevant articles and documents

A convenient synthesis of some new indeno[1,2-b]pyridines and indeno[1,2-b] thieno[3,2-e]pyridine derivatives with potential biological activity

3-Cyano-5-oxo-4(2-thienyl)-indeno[1,2-b]pyridin-2-[1H]thione 3 was prepared from indanone 1 with arylidene cyanoacetamide or from arylideneindanone 2 with cyanoacetamide. S-Alkylation of 3 with halogenated compounds afforded compounds 4a-h. Compounds 4d-h underwent ring closure with sodium ethoxide to produce indenothienopyridines 5a-e, respectively. Treatment of 3 using ethylchoroacetate or chloroacetone gave compounds 6 and 7, respectively. Compounds 5a and 5d were reacted with carbon disulphide in pyridine to give compounds 8a and 8b. Most of the synthesized compounds were screened in vitro for their antimicrobial activities against four species of bacteria and six species of fungi using Chloramphenicol (5%) and Terbinafine (5%) as a standard.