952720-97-7Relevant articles and documents
A convenient synthesis of some new indeno[1,2-b]pyridines and indeno[1,2-b] thieno[3,2-e]pyridine derivatives with potential biological activity
El-Ossaily, Yasser A.
, p. 1109 - 1117 (2008/02/01)
3-Cyano-5-oxo-4(2-thienyl)-indeno[1,2-b]pyridin-2-[1H]thione 3 was prepared from indanone 1 with arylidene cyanoacetamide or from arylideneindanone 2 with cyanoacetamide. S-Alkylation of 3 with halogenated compounds afforded compounds 4a-h. Compounds 4d-h underwent ring closure with sodium ethoxide to produce indenothienopyridines 5a-e, respectively. Treatment of 3 using ethylchoroacetate or chloroacetone gave compounds 6 and 7, respectively. Compounds 5a and 5d were reacted with carbon disulphide in pyridine to give compounds 8a and 8b. Most of the synthesized compounds were screened in vitro for their antimicrobial activities against four species of bacteria and six species of fungi using Chloramphenicol (5%) and Terbinafine (5%) as a standard.