31186-12-6Relevant articles and documents
Rogers et al.
, p. 393 (1971)
Synthesis and structure-activity relationships of dehydroaltenusin derivatives as selective DNA polymerase α inhibitors
Kuramochi, Kouji,Fukudome, Keishi,Kuriyama, Isoko,Takeuchi, Toshifumi,Sato, Yoshihiro,Kamisuki, Shinji,Tsubaki, Kazunori,Sugawara, Fumio,Yoshida, Hiromi,Mizushina, Yoshiyuki
experimental part, p. 7227 - 7238 (2010/03/03)
Herein, we describe the synthesis and structure-activity relationships of dehydroaltenusin derivatives as inhibitors of a mammalian DNA polymerase α. We have newly synthesized nine dehydroaltenusin derivatives modified at the side chains or benzoquinone m
Total synthesis of dehydroaltenusin
Takahashi, Shunya,Kamisuki, Shinji,Mizushina, Yoshiyuki,Sakaguchi, Kengo,Sugawara, Fumio,Nakata, Tadashi
, p. 1875 - 1877 (2007/10/03)
First total synthesis of dehydroaltenusin, a natural enzyme inhibitor, is described. The key step involves Suzuki-couplig reaction of aryl triflate prepared from 2,4,6-trihydroxy benzoic acid with a catechol-derived boronic acid. The synthetic sample was