3119-93-5Relevant articles and documents
Aminosquaraines as potential photodynamic agents: Synthesis and evaluation of in vitro cytotoxicity
Magalh?es,Gra?a, Vania C.,Calhelha, Ricardo C.,Ferreira, Isabel C.F.R.,Santos, Paulo F.
, p. 4467 - 4470 (2017)
The synthesis of several aminosquaraine cationic dyes displaying strong absorption within the so-called phototherapeutic window (650–850 nm) is described. Their cytotoxicity, under dark and illuminated conditions, was tested against several human tumor cell lines (breast, lung, cervical and hepatocellular carcinomas) and non-tumor porcine liver primary cells. All compounds showed to inhibit the growth of the tumor cells upon irradiation more than in the absence of light, in more or less extension, clearly exhibiting photodynamic activity. The photosensitizing ability against some cell lines, together with the low toxicity for the non-tumor primary PLP2 cells displayed by some of the compounds synthetized, turns them into potential candidates as photosensitizers for PDT.
Host-guest assembly of squaraine dye in cucurbit[8]uril: Its implication in fluorescent probe for mercury ions
Xu, Yongqian,Panzner, Matthew J.,Li, Xiaopeng,Youngs, Wiley J.,Pang, Yi
, p. 4073 - 4075 (2010)
The binding interactions between SQ2 squaraine dye and cucurbit[8]uril (CB8) effectively removes the aggregation of SQ2 in aqueous solution by forming a 1:1 inclusion complex. The resulting SQ2·CB8 complex exhibits highly selective fluorescence quenching by Hg2+ ions, as a result of the synergetic binding between CB8, SQ2 and metal cation.
Ability of carbazole salts, inhibitors of Alzheimer β-amyloid fibril formation, to cross cellular membranes
Saengkhae, Chantarawan,Salerno, Milena,Ades, Dominique,Siove, Alain,Le Moyec, Laurence,Migonney, Veronique,Garnier-Suillerot, Arlette
, p. 124 - 131 (2007)
Alzheimer's disease is characterized by the presence of β-amyloid fibril formation. The inhibition of this peptide accumulation may be a prevention method for Alzheimer's disease. Several classes of molecules have been reported to inhibit β-amyloid fibril formation and among them carbazoles. However, very few studies have been performed to determine the destination of such molecules in vivo and especially if they can pass the blood brain barrier. The aim of this paper is to study whether carbazoles could pass the blood brain barrier, i.e. if they can circumvent ATP Binding Cassette (ABC) transporters such as P-glycoprotein (P-gp) and Multidrug Resistance-associated protein (MRP1) which efficiently limit drug brain uptake. For this purpose we have synthesized a fluorescent derivative of carbazole benzothiazolium iodide 1,2 disubstituted ethylene (referred as carbazole thiazole: CT), which can be easily detected and followed in the pre-trial study phases in cells or in tissue. We use cellular models overexpressing P-gp and MRP1. Our results show that: i) CT is able to cross membranes and to penetrate rapidly inside the cells, ii) CT is a P-gp substrate and consequently its accumulation in P-gp overexpressing cells is very low, iii) CT is a poor MRP1 substrate. In addition once inside the cells, CT rapidly binds to DNA and is then slowly reduced by intracellular reducing agents. In conclusion, the efficiency of carbazole derivatives in inhibiting the β-amyloid formation in vivo could be highly compromised because, as P-gp substrates, they will probably not cross the blood brain barrier.
An NIR fluorescent probe of uric HSA for renal diseases warning
Li, Haidong,Yao, Qichao,Fan, Jiangli,Du, Jianjun,Wang, Jingyun,Peng, Xiaojun
, p. 79 - 85 (2016)
Diseases of the kidney, including acute kidney injury, nephritic syndromes, chronic kidney disease, and renal cysts, are accompanied by a series of characteristic clinical features. Human Serum Albumin (HSA) is regarded as an important biomarker for early warning of kidney diseases among them. To the best of our knowledge, although some fluorescent probes of HSA had reported in blood plasma under high concentrations of HSA, most of them could not reach the detection sensitivity of low concentrations of HSA in urine. In this work, an NIR fluorescent probe NIR-HSA for HSA based on TICT mechanism is reported, which can used in solution detection with 8.83-fold fluorescence enhancement, rapid response (completed within 5 s), excellent sensitivity (DL 26.16 nM), and excellent stability. In human urine detection, NIR-HSA clearly demonstrated perfect recovery property, and good potential to be applied to detect trace HSA for warning of critical diseases.
Synthesis of innovative colorants based on cyanine dye and their FRET efficiency to reduce the emission of fluorescence for LCD color filter
Kwon, Hye-Sun,Yoo, Jae-Sung,Lee, Hyun-Young,Choi, Jae-Hong
, p. 2545 - 2548 (2015)
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A photosensitizer with conformational restriction for enhanced photodynamic therapy
Du, Jianjun,Fan, Jiangli,Huang, Daipeng,Huang, Haiqiao,Long, Saran,Peng, Xiaojun
supporting information, p. 9100 - 9103 (2021/09/14)
A rigid hemicyanineCSZ-Jand a flexible moleculeESZ-Jwere synthesized. In particular, the conformationally restrainedCSZ-Jhad higher fluorescence quantum yields, longer fluorescence lifetimes and higher triplet state quantum yields.CSZ-Jcould generate highly cytotoxic ROS simultaneouslyviatype I and type II processes. This will contribute to the design and development of new photosensitizers in the future.
