31191-43-2Relevant academic research and scientific papers
Non-destructive erasable molecular switches and memory using light-driven twisting motions
Kawamoto, Masuki,Shiga, Natsuki,Takaishi, Kazuto,Yamashita, Takashi
, p. 8344 - 8346 (2010)
Novel types of chiroptical switches and memory with non-destructive readout that are entirely optically controlled for molecular devices in solution and neat films.
Identification of a novel click-derived 1,2,3-triazole as selective Hg2+ ion detector: computational and experimental investigations
Ujan, Rabail,Arshad, Nasima,Perveen, Fouzia,Channar, Pervaiz Ali,Lal, Bhajan,Hussain, Mumtaz,Hussain, Zahid,Saeed, Aamer,Shehzadi, Syeda Aaliya
, p. 6377 - 6388 (2021)
A new triazole-substituted compound (7), namely {5-((2-methyl-4-(3-methyl-4-(prop-2-ynyloxy) benzyl) phenoxy) methyl)-1-(3-(nitrophenoxy) propyl)-1h-1, 2, 3-triazole}, was synthesized through the coupling of azido and propargylated precursors via click ap
Light-driven reversible handedness inversion in self-organized helical superstructures
Mathews, Manoj,Zola, Rafael S.,Hurley, Shawn,Yang, Deng-Ke,White, Timothy J.,Bunning, Timothy J.,Li, Quan
, p. 18361 - 18366 (2010)
We report here a fast-photon-mode reversible handedness inversion of a self-organized helical superstructure (i.e., a cholesteric liquid crystal phase) using photoisomerizable chiral cyclic dopants. The two light-driven cyclic azobenzenophanes with axial
Piperazine substituted 1, 3 - di-substituted urea compound and piperazine substituted amide compounds and a method for its preparation and use
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Paragraph 0155-0157, (2017/04/22)
The present invention relates to a class of piperazine substituted 1,3-disubstitued urea compounds and piperazine substituted amide compounds, or pharmaceutically acceptable salts of the piperazine substituted 1,3-disubstitued urea compounds and the piper
Optically active compound and its use
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Paragraph 0047-0048, (2016/12/22)
PROBLEM TO BE SOLVED: To provide a new compound which varies optical rotation by irradiation with light. SOLUTION: The optically active compound is represented by formula (1) (wherein X is each independently -NH2, -N(CH3)2, -H, -F, -I, -Br, -Cl, -COOH or the like; and a and b are integers in the range of 1-6). COPYRIGHT: (C)2011,JPOandINPIT
Incorporation of piperazino functionality into 1,3-disubstituted urea as the tertiary pharmacophore affording potent inhibitors of soluble epoxide hydrolase with improved pharmacokinetic properties
Huang, Shao-Xu,Li, Hui-Yuan,Liu, Jun-Yan,Morisseau, Christophe,Hammock, Bruce D.,Long, Ya-Qiu
supporting information; experimental part, p. 8376 - 8386 (2011/02/21)
The inhibition of the mammalian soluble epoxide hydrolase (sEH) is a promising new therapy in the treatment of hypertension, inflammation, and other disorders. However, the problems of limited water solubility, high melting point, and low metabolic stabil
Improved model of lanosterol 14α-demethylase by ligand-supported homology modeling: Validation by virtual screening and azole optimization
Sheng, Chunquan,Wang, Wenya,Che, Xiaoying,Dong, Guoqiang,Wang, Shengzheng,Ji, Haitao,Miao, Zhenyuan,Yao, Jianzhong,Zhang, Wannian
experimental part, p. 390 - 397 (2010/11/18)
Lanosterol 14α-demethylase (CYP51) is an important target for antifungal drugs. An improved three-dimensional model of CYP51 from Candida albicans (CACYP51) was constructed by ligand-supported homology modeling and molecular dynamics simulations. The accuracy of the constructed model was evaluated by its performance in a small-scale virtual screen. The results show that known CYP51 inhibitors were efficiently discriminated by the model, and it performed better than our previous CACYP51 model. The active site of CACYP51 was characterized by multiple copy simultaneous search (MCSS) calculations. On the basis of the MCSS results, a series of novel azoles were designed and synthesized, and they showed good in vitro antifungal activity with a broad spectrum. The MIC80 value of four of these compounds against C. albicans is 0.001 μgmL-1, indicating that they are promising leads for the discovery of novel antifungal agents.
New azoles with potent antifungal activity: Design, synthesis and molecular docking
Che, Xiaoying,Sheng, Chunquan,Wang, Wenya,Cao, Yongbing,Xu, Yulan,Ji, Haitao,Dong, Guoqiang,Miao, Zhenyuan,Yao, Jianzhong,Zhang, Wannian
scheme or table, p. 4218 - 4226 (2009/12/09)
In response to the urgent need for novel antifungal agents with improved activity and broader spectrum, computer modeling was used to rational design novel antifungal azoles. On the basis of the active site of lanosterol 14α-demethylase from Candida albicans (CACYP51), a series of new azoles with substituted-phenoxypropyl piperazine side chains were rational designed and synthesized. In vitro antifungal activity assay indicates that the new azoles show good activity against most of the tested pathogenic fungi. Interestingly, the designed compounds are also active against an azole-resistant clinical strain. Compared to fluconazole and itraconazole, several compounds (such as 12i, 12j and 12n) show higher antifungal activity and broader spectrum, which are promising leads for the development of novel antifungal agents.
IMIDAZO-THIAZOLE DERIVATIVES AS PROTEIN KINASE INHIBITORS
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Page/Page column 131, (2009/07/03)
Compounds of formula I that inhibit protein kinases, compositions containing the compounds and methods of treating diseases using the compounds are disclosed. Formula I and therapeutically acceptable salts, prodrugs and salts of prodrugs thereof, wherein X is CH or N; A1 is R1, OR1. NHR1, N(R1)2, NHC(O)R1, NHC(O)NHR1, NHC(O)N(R1)2, NHC(O)OR1, C(O)NHR1, C(O)N(R1)2, C=NOR1, or C(NH2)NOC(O)R1;
Muscarinic acetylcholine receptor antagonists
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Page/Page column 17, (2008/06/13)
Muscarinic Acetylcholine Receptor Antagonists and methods of using them are provided.
