31197-30-5

Usage

Uses

Used in Pharmaceutical Research:
1-(3-Bromophenyl)piperazine is used as a building block in the synthesis of various pharmaceutical drugs, particularly for those targeting the nervous system. Its unique chemical structure and properties make it a valuable component in the development of new medications.
Used in Scientific Research:
As a compound of interest in the field of pharmacology, 1-(3-Bromophenyl)piperazine is used in scientific research to study its behavior and impact on the nervous system. This research aims to explore its potential therapeutic applications and contribute to the advancement of medical knowledge.
Used in Chemical Property Studies:
Due to its distinctive chemical properties, 1-(3-Bromophenyl)piperazine is utilized in studies that investigate the effects of bromine substitution on phenyl rings. This research can provide insights into the reactivity and stability of similar compounds, furthering the understanding of chemical behavior in various contexts.

InChI:InChI=1/C10H13BrN2/c11-9-2-1-3-10(8-9)13-6-4-12-5-7-13/h1-3,8,12H,4-7H2

Upstream product

• 821-48-7 bis-(2-chloroethyl)amine hydrochloride 
• 591-19-5 m-Bromoaniline 

Downstream Products

• 65386-40-5 1-(2-benzyl-thiazol-4-ylmethyl)-4-(3-bromo-phenyl)-piperazine 
• 78069-80-4 1-(3-Bromo-phenyl)-4-(3-nitro-pyridin-4-yl)-piperazine 
• 78091-25-5 4-[4-(3-Bromo-phenyl)-piperazin-1-yl]-pyridin-3-ylamine 
• 65385-49-1 1-(3-bromo-phenyl)-4-[5-(4-chloro-phenyl)-furan-2-carbonyl]-piperazine 
• 65386-15-4 1-(3-bromo-phenyl)-4-(2-methyl-thiazol-4-ylmethyl)-piperazine 
• 926646-65-3 1-[3-(3-furyl)phenyl]piperazine 
• 926646-64-2 1-[3-(3-thienyl)phenyl]piperazine 
• 327030-39-7 1,1-dimethylethyl 4-(3-bromophenyl)piperazine-1-carboxylate 
• 1401688-33-2 C₂₄H₂₁BrN₄ 
• 1608496-75-8 C₂₀H₂₃N₃O 
• 1257704-57-6 {[8-(4-methanesulfonyl-phenyl)-[1,2,4]triazolo[1,5-a]-pyridin-2-yl]-[3-(4-methyl-piperazin-1-yl)-phenyl]-amine} 
• 747413-17-8 1-bromo-3-(4-methylpiperazin-1-yl)benzene 
• 540752-87-2 tert-butyl 4-[3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]piperazine-1-carboxylate 

Relevant academic research and scientific papers

MONOACYLGLYCEROL LIPASE INHIBITORS

Provided are compounds of formula (I), or a pharmaceutically acceptable salt or solvate thereof: Also provided are compositions comprising compounds of formula (I). The compounds and compositions are also provided for use as medicaments, for example as medicaments useful in the treatment of a condition modulated by monoacylglycerol lipase (MAGL). Also provided are the use of compounds and compositions for the inhibition of monoacylglycerol lipase (MAGL).

4-Substituted-2-phenylquinazolines as inhibitors of BCRP

We investigated several 2-phenylquinazolines with different substitutions at position 4 for their BCRP inhibition. Compounds with phenyl ring attached via an amine-containing linker at position 4 were found to be potent inhibitors of BCRP. In general compounds with meta substitution of phenyl ring at position 4 were found to have higher inhibitory effect, compound 12 being the most potent and selective towards BCRP.

Synthesis and antitumor activity of novel pyrimidinyl pyrazole derivatives. II. Optimization of the phenylpiperazine moiety of 1-[5-methyl-1-(2-pyrimidinyl)-4-pyrazolyl]-3-phenylpiperazinyl-1-trans-propenes.

A series of novel 3-substituted-1-[5-methyl-1-(2-pyrimidinyl)-4-pyrazolyl]-1-trans-propenes in order to improve the in vitro and in vivo activity of our prototype 3-[4-(3-chlorophenyl)-1-piperazinyl]-1-[5-methyl-1-(2-pyrimidinyl)-4-pyrazolyl]-1-trans-propene (2) were synthesized and evaluated by assays of growth inhibition against several tumor cell lines in vitro and antitumor activity against some tumor models when dosed both intraperitoneally and orally in vivo. Compounds 7a and 7e, the 3,5-difluorophenyl and 3,5-dichlorophenyl analogues of 2, respectively, showed significantly more potent cytotoxicity than 2 in vitro and potent antitumor activities without causing decrease of body temperature related to side effects.