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4-[4-(3-bromophenyl)piperazin-1-yl]pyridin-3-amine is a complex organic compound with the molecular formula C18H18BrN5. It is characterized by a pyridine ring, which is a six-membered aromatic ring containing two nitrogen atoms, and a piperazine ring, which is a six-membered ring with two nitrogen atoms. The compound features a 3-bromophenyl group attached to the piperazine, which introduces a bromine atom at the 3-position of the phenyl ring. This chemical structure is of interest in medicinal chemistry, particularly in the development of drugs targeting the dopamine D2 receptor, due to its potential to modulate receptor activity. The presence of the bromine atom can influence the compound's lipophilicity and binding affinity, which are important factors in drug design.

78091-25-5

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78091-25-5 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 78091-25-5 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 7,8,0,9 and 1 respectively; the second part has 2 digits, 2 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 78091-25:
(7*7)+(6*8)+(5*0)+(4*9)+(3*1)+(2*2)+(1*5)=145
145 % 10 = 5
So 78091-25-5 is a valid CAS Registry Number.

78091-25-5SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 13, 2017

Revision Date: Aug 13, 2017

1.Identification

1.1 GHS Product identifier

Product name 4-[4-(3-bromophenyl)piperazin-1-yl]pyridin-3-amine

1.2 Other means of identification

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Other names -

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

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More Details:78091-25-5 SDS

78091-25-5Downstream Products

78091-25-5Relevant academic research and scientific papers

Quantitative Structure Activity Relationship in 3,4-Disubstituted Pyridines and 1-(3"-Amino-4"-pyridyl)-4-arylpiperazines

Saxena, Anil K.,Arunamurthy, V.,Patnaik, G. K.,Jain, Padam C.,Anand, Nitya

, p. 873 - 878 (2007/10/02)

In a study of the SAR in 3,4-disubstituted pyridines, it has been observed that both stimulant and anticonvulsant activities are confined to 1-(3'-amino-4'-pyridyl)-4-phenylpiperazines, and further the substitution in the phenyl ring can dissociate these activities of this prototype.In order to understand the relationship of electronic (?), hydrophobic (?) and stereo (Es) parameters of the substituents with anticonvulsant activity, a multi-parameter regression analysis of twelve compounds of this group has been carried out, which suggests that hydrophobic and electronic factors are more important and anticonvulsant activity can be enhanced by compounds having log P = 2.7- 3.1 0= 2.67 (Eq. 5) and (log P)0= 3.09 (Eq. 6)> with an electron withdrawing substituent in the phenyl ring.

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