31206-12-9Relevant academic research and scientific papers
Hyperbranched aromatic poly(ether ketone) functionalized with TEMPO as a heterogeneous catalyst for aerobic oxidation of alcohols
Shi, Ying,Nabae, Yuta,Hayakawa, Teruaki,Kakimoto, Masa-Aki
, p. 1923 - 1928 (2015/02/18)
A hyperbranched aromatic poly(ether ketone) functionalized with 2,2,6,6-tetramethylpiperidine-1-oxyl (TEMPO/HBPEK) was investigated as a novel heterogeneous catalyst for aerobic oxidation of alcohols. The TEMPO/HBPEK contained 2 mmol g-1 TEMPO and had a turnover number (TON) of 46 compared to commercial TEMPO with a TON of 60, indicating good catalytic activity and selectivity for the aerobic oxidation of benzyl alcohol. This material can be used as a recyclable heterogeneous catalyst by grafting it onto insoluble supports such as carbon black (TEMPO/HBPEK/CB) or polyimide nanoparticles (TEMPO/HBPEK/PI), whereas the bare TEMPO/HBPEK acts as a homogeneous catalyst. These heterogeneous catalysts had TONs of 27 and 22, respectively, indicating greater catalytic activity than the commercially available heterogeneous catalyst, TEMPO immobilized on polystyrene, which had a TON less than 1.
Benzamidine derivatives and their use as anti-coagulants
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Page column 45, (2010/02/04)
This invention is directed to benzamidine derivatives which are useful as anti-coagulants. This invention is also directed to pharmaceutical compositions containing the compounds of the invention, and methods of using the compounds to treat disease-states characterized by thrombotic activity.
Design, synthesis, and activity of 2,6-diphenoxypyridine-derived factor Xa inhibitors
Phillips, Gary,Davey, David D.,Eagen, Keith A.,Koovakkat, Sunil K.,Liang, Amy,Ng, Howard P.,Pinkerton, Michael,Trinh, Lan,Whitlow, Marc,Beatty, Alicia M.,Morrissey, Michael M.
, p. 1749 - 1756 (2007/10/03)
A novel series of 2,6-diphenoxypyridines has been designed to inhibit factor Xa, a serine protease strategically located in the coagulation cascade. The evolution from the photochemically unstable bisamidine (Z,Z)- BABCH to potent bisamidine compounds with a pyridine heterocycle as the core scaffold has been achieved. The most potent compound in the series, 6h, has a K(i) for human factor Xa of 12 nM. The selectivity of 6h against bovine trypsin and human thrombin was greater than 90- and 1000-fold, respectively. Two proposed modes of binding of 6h to factor Xa are made based on the crystal structures of 6h by itself and of 6h bound to bovine trypsin.
Benzamidine derivatives and their use as anti-coagulants
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, (2008/06/13)
This invention is directed to benzamidine derivatives which are useful as anti-coagulants. This invention is also directed to pharmaceutical compositions containing the compounds of the invention, and methods of using the compounds to treat disease-states characterized by thrombotic activity.
Ring-based analogues of pentamidine versus P. carinii pneumonia in culture
Delia, Thomas J.,Nagarajan,Queener, Sherry F.,Bartlet, Marilyn S.
, p. 2367 - 2370 (2007/10/03)
The synthesis of aromatic ring-based pentamidine analogues, in which the aliphatic bridge has been replaced by benzene, pyridine, or pyrimidine has been accomplished in two steps. Compounds containing benzene and pyridine as the central core of the molecule have demonstrated activity against PCP in culture.
Antiparasitic Agents: Part VI - Synthesis of 1,2-, 1,3,- and 1,4-Bis(4-substituted aryloxy)benzenes and their Biological Activities
Chauhan, P. M. S.,Niyer, R.,Bhakuni, D. S.,Shankhdhar, V.,Guru, P.Y.,Sen, A. B.
, p. 38 - 42 (2007/10/02)
Several 1,2-, 1,3-, 1,4-bis(4-amidinophenoxy)benzenes (8-10); 1,2-, 1,3-, 1,4-bis(4-amidinobenzyloxy)benzenes (14-16) and 1,2-, 1,3-, 1,4-bis(4-amidinophenoxymethyl)benzenes (26-28) and the corresponding amidoximes (17-19), (29-31) and 33 have been synthe
