312299-84-6Relevant articles and documents
Novel sulfonate analogues of combretastatin A-4: Potent antimitotic agents
Gwaltney II, Stephen L.,Imade, Hovis M.,Barr, Kenneth J.,Li, Qun,Gehrke, Laura,Credo,Warner, Robert B.,Lee, Jang Yun,Kovar, Peter,Wang, Jieyi,Nukkala, Michael A.,Zielinski, Nicolette A.,Frost, David,Ng, Shi-Chung,Sham, Hing L.
, p. 871 - 874 (2001)
Sulfonate analogues of combretastatin A-4 have been prepared. These compounds compete with colchicine and combretastatin A-4 for the colchicine binding site on tubulin and are potent inhibitors of tubulin polymerization and cell proliferation. Importantly, these compounds also inhibit the proliferation of P-glycoprotein positive (+) cancer cells, which are resistant to many other antitumor agents.
