312299-85-7Relevant academic research and scientific papers
Cell proliferation inhibitors
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, (2008/06/13)
Compounds having formula (I) inhibit cellular proliferation. Processes for the preparation of the compounds, pharmaceutical compositions containing the compounds, and methods of treatment using the compounds are disclosed.
Novel sulfonate analogues of combretastatin A-4: Potent antimitotic agents
Gwaltney II, Stephen L.,Imade, Hovis M.,Barr, Kenneth J.,Li, Qun,Gehrke, Laura,Credo,Warner, Robert B.,Lee, Jang Yun,Kovar, Peter,Wang, Jieyi,Nukkala, Michael A.,Zielinski, Nicolette A.,Frost, David,Ng, Shi-Chung,Sham, Hing L.
, p. 871 - 874 (2007/10/03)
Sulfonate analogues of combretastatin A-4 have been prepared. These compounds compete with colchicine and combretastatin A-4 for the colchicine binding site on tubulin and are potent inhibitors of tubulin polymerization and cell proliferation. Importantly, these compounds also inhibit the proliferation of P-glycoprotein positive (+) cancer cells, which are resistant to many other antitumor agents.
