312300-42-8

Basic information

• Product Name: 6-METHOXY-PYRIDINE-3-SULFONYL CHLORIDE
• Synonyms: 6-METHOXY-PYRIDINE-3-SULFONYL CHLORIDE;6-Methoxypyridine-3-sulphonyl chloride;3-(Chlorosulphonyl)-6-methoxypyridine;5-(Chlorosulphonyl)-2-methoxypyridine;6-(Methyloxy)-3-pyridinesulfonyl chloride
• CAS NO: 312300-42-8
• Molecular Formula: C₆H₆ClNO₃S
• Molecular Weight: 207.63
• Mol File: 312300-42-8.mol
• Article Data: 11

Chemical Properties

• Boiling Point: 320.433 °C at 760 mmHg
• Flash Point: 147.593 °C
• Appearance: White/Crystalline Low Melting Solid
• Density: 1.449 g/cm³
• Vapor Pressure: 0.001mmHg at 25°C
• Refractive Index: 1.534
• Storage Temp.: Inert atmosphere,Store in freezer, under -20°C
• PKA: -3.56±0.11(Predicted)
• CAS DataBase Reference: 6-METHOXY-PYRIDINE-3-SULFONYL CHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 6-METHOXY-PYRIDINE-3-SULFONYL CHLORIDE(312300-42-8)
• EPA Substance Registry System: 6-METHOXY-PYRIDINE-3-SULFONYL CHLORIDE(312300-42-8)

Safety Data

• Hazard Codes: Xi
• Statements: 36-43
• Safety Statements: 26-36/37
• Hazardous Substances Data: 312300-42-8(Hazardous Substances Data)

Usage

Uses

6-Methoxypyridine-3-sulfonyl Chloride is used in the synthesis of pharmaceuticals. It is used as a reactant in the preparation of sulfonate analogs of combretastatin A-4 as potent antimitotic agents. Also used in the preparation of compounds with H+,K+-ATPase inhibitory action and gastric acid secretion inhibitory activities.

InChI:InChI=1/C6H6ClNO3S/c1-11-6-3-2-5(4-8-6)12(7,9)10/h2-4H,1H3

Upstream product

• 13472-85-0 2-methoxy-5-bromopyridine 
• 10167-97-2 2-amino-5-methoxypyridine 
• 6628-77-9 6-methoxy-pyridin-3-ylamine 

Downstream Products

• 856955-32-3 6-methoxypyridine-3-sulfonamide 
• 1138034-16-8 sodium 6-methoxypyridine-3-sulfinate 
• 881676-92-2 1-[(6-methoxypyridin-3-yl)sulfonyl]-5-phenyl-1H-pyrrole-3-carbaldehyde 
• 312299-87-9 3,4,5-trimethoxyphenyl 6-methoxy-3-pyridinesulfonate 

Relevant articles and documents

DOCK1-INHIBITING COMPOUND AND USE THEREOF

Provided is a compound that is usable as an active ingredient of an anticancer agent. Preferably provided is a compound that has DOCK1-inhibiting activity and exerts an anticancer effect based on the activity. A compound represented by the following formula (A) or a salt thereof: wherein X represents a carbon atom or a nitrogen atom; Y represents an oxygen atom, a hydroxy group, or a hydrocarbon group; R1 and R2 are different, and each represents a hydrogen atom or a group represented by the following formula (A-1): (wherein R6 represents a pyrrolidino group or a phenyl group, and n2 is 0 or 1) ; R3 represents -CO-R7 (wherein R7 is an alkoxy group, an alkyl group, or an alkylamino group), a 1,3-oxazole group, an alkylhydroxy group, a hydrogen atom, or an oxygen atom; R4 represents a hydrogen atom, an oxygen atom, or a hydrocarbon group in which one or more hydrogen atoms may be replaced by one or more substituents; R5 represents a halogen atom, a halogenated alkyl group, or a halogenated alkylthio group; and n1 is an integer of 0 to 5; and

Proton pump inhibitors

A proton pump inhibitor containing a compound represented by the formula (I) wherein X and Y are the same or different and each is a bond or a spacer having 1 to 20 carbon atoms in the main chain, R 1 is an optionally substituted hydrocarbon group or an optionally substituted heterocyclic group, R 2 , R 3 and R 4 are the same or different and each is a hydrogen atom, an optionally substituted hydrocarbon group, an optionally substituted thienyl group, an optionally substituted benzo[b]thienyl group, an optionally substituted furyl group, an optionally substituted pyridyl group, an optionally substituted pyrazolyl group, an optionally substituted pyrimidinyl group, an acyl group, a halogen atom, a cyano group or a nitro group, R 5 and R 6 are the same or different and each is a hydrogen atom or an optionally substituted hydrocarbon group, which has a superior proton pump action and shows an antiulcer activity and the like after conversion to a proton pump inhibitor in the body, or a salt thereof. or a prodrug thereof is provided.

COMPOUNDS AND METHODS FOR TREATING INFLAMMATORY AND FIBROTIC DISORDERS

Disclosed are compounds and methods for treating inflammatory and fibrotic disorders, including methods of modulating a stress activated protein kinase (SAPK) system with an active compound, wherein the active compound exhibits low potency for inhibition of the p38 MAPK; and wherein the contacting is conducted at a SAPK-modulating concentration that is at a low percentage inhibitory concentration for inhibition of the p38 MAPK by the compound. Also disclosed are derivatives and analogs of pirfenidone, useful for modulating a stress activated protein kinase (SAPK) system.