312307-41-8Relevant academic research and scientific papers
Acid-mediated cyclization of 3-benzoyl-2-cyanobutyronitrile to 2-amino-4-methyl-5-phenylfuran-3-carbonitrile
Watanuki, Susumu,Sakamoto, Shuichi,Harada, Hironori,Kikuchi, Kazumi,Kuramochi, Takahiro,Kawaguchi, Ken-Ichi,Okazaki, Toshio,Tsukamoto, Shin-Ichi
, p. 127 - 130 (2007/10/03)
Cyclization of 3-benzoyl-2-cyanobutyronitrile to 2-amino-4-methyl-5-phenylfuran-3-carbonitrile was effected under acidic conditions, rather than the basic conditions previously reported. Since treatment with trifluoroacetic acid (TFA) at room temperature is very mild, 2-amino-4-methyl-5-phenylfuran-3-carbonitriles containing various functional groups can be accessed via this route.
