26551-48-4

Upstream product

• 25333-24-8 3-benzoylpropionic acid methyl ester 
• 2051-95-8 succinylbenzene 
• 598-21-0 2-Bromoacetyl bromide 
• 177421-87-3 methyl 3-phenyl-2H-azirine-2-acetate 
• 98-88-4 benzoyl chloride 
• 20718-17-6 2-(dimethyl(oxo)-λ⁶-sulfaneylidene)-1-phenylethan-1-one 
• 96-32-2 bromoacetic acid methyl ester 

Downstream Products

• 1008-76-0 4,5-dihydro-5-phenyl-2(3H)-furanone 
• 25333-24-8 3-benzoylpropionic acid methyl ester 
• 56015-01-1 methyl 4-hydroxy-4-phenyl-(E)-but-2-enoate 
• 78861-23-1 cis-Methyl 3,4-epoxy-4-phenylbutanoate 
• 37779-49-0 methyl 3-oxo-4-phenylbutanoate 
• 729581-01-5 C₁₉H₁₈N₂O₂S 
• 729580-99-8 C₁₉H₁₈N₂O₂S 
• 729581-02-6 C₁₈H₁₄Cl₂N₂O₂S 
• 729580-96-5 C₁₈H₁₅BrN₂O₂S 
• 723751-23-3 C₂₀H₁₈N₂O₃S 
• 729581-03-7 C₁₈H₁₄ClFN₂O₂S 
• 729580-97-6 C₁₈H₁₅ClN₂O₂S 
• 928152-28-7 methyl (2-(4-(2-methoxyphenyl)-piperazin-1-yl)-4-phenylthiazol-5-yl)-acetate 
• 312307-41-8 3-benzoyl-4,4-dicyano-butyric acid methyl ester 

Relevant academic research and scientific papers

Mechanism of the Lanthanum Bromide Assisted Electrochemical Aldolization of α-Bromo Ketones

Linear sweep voltammetry, preparative electrolyses under a variety of experimental conditions, and trapping experiments have been used to explore the mechanism of the formation of the aldol 2-benzoyl-1-phenylpropanol by electrochemical reduction of α-brom

Continuous multistep synthesis of 2-(azidomethyl)oxazoles

An efficient three-step protocol was developed to produce 2-(azidomethyl)oxazoles from vinyl azides in a continuous-flow process. The general synthetic strategy involves a thermolysis of vinyl azides to generate azirines, which react with bromoacetyl brom

α,α-Alkylation-Halogenation and Dihalogenation of Sulfoxonium Ylides. A Direct Preparation of Geminal Difunctionalized Ketones

A one-pot alkylation–halogenation of ketosulfoxonium ylides in the presence of alkyl halides is described. The method furnishes several gem-difunctionalized haloketones (an alkyl and F, Cl, Br, or I) in good yields. Replacing alkyl halides with a mixture of electrophilic halogen species and various halide anions led to gem-dihalogenated ketones containing a combination of the same or two different halogens. Kinetic isotopic effects as well as reaction kinetic experiments give insight to the mechanism of these reactions.

An expeditious synthesis of methyl 5-(2-amino 4-arylthiazolyl) acetates using microwave irradiation

2,4,5-Trisubstituted thiazole derivatives can be prepared conveniently by condensation of methyl 3-bromo-3-aroyl propionates with thiourea and (un)substituted phenyl thiourea under microwave irradiation in good yields. The structures of the newly synthesized compounds are characterized by spectral data and elemental analysis.

Acid-mediated cyclization of 3-benzoyl-2-cyanobutyronitrile to 2-amino-4-methyl-5-phenylfuran-3-carbonitrile

Cyclization of 3-benzoyl-2-cyanobutyronitrile to 2-amino-4-methyl-5-phenylfuran-3-carbonitrile was effected under acidic conditions, rather than the basic conditions previously reported. Since treatment with trifluoroacetic acid (TFA) at room temperature is very mild, 2-amino-4-methyl-5-phenylfuran-3-carbonitriles containing various functional groups can be accessed via this route.

4-aryl oxazoles

Novel oxazole derivatives of the formula STR1 (wherein R1 is hydrogen or a straight, branched or cyclic alkyl group of 1 to 6 carbon atoms, R2 is hydrogen, halogen, trifluoromethyl, or a straight, branched or cyclic alkylthio of 1 to 3 carbon atoms, and n is 1 or 2) or pharmaceutically acceptable salts or esters thereof are synthesized through several routes. The derivatives have hypoglycemic, glucose tolerance improving and insulin sensitivity increasing activities and are of value as antidiabetic drugs.

Preparation and Rearrangement of cis-Methyl 3,4-Epoxy-4-(4'-methylphenyl)butanoate

AlCl3 catalysed bromination of methyl 4-keto-4-(4'-methylphenyl)butanoate (2) is regioselective and furnishes methyl 3-bromo-4-keto-4-(4'-methylphenyl)butanoate (3). 3 on NaBH4 reduction in the presence of NaHCO3 furnishes a mixture of cis-methyl 3,4-epoxy-4-(4'-methylphenyl)butanoate (9), methyl (E)-4-hydroxy-4-(4'-methylphenyl)but-2-enoate (12), 4-(4'-methylphenyl)butanolide (26) and 2. 12 can be transformed to 1 on heating with NaOH-ethanol.BF3 catalysed rearrangement of 9 furnishes methyl 3-keto-4-(4'-methylphenyl)butanoate (17).The sequence of reactions 2->3->9->17 constitutes an interesting example of ketone transposition and provides a convenient route for the preparation of 17 from the readily available 2.