17229-14-0

Basic information

• Product Name: Ethyl 2-chloroethoxyl acetic acid
• Synonyms: Ethyl 2-chloroethoxyl acetic acid;(2-Chloroethoxy)acetic acid ethyl ester;Ethyl 2-(chloroethoxyl)acetate;Ethyl-2-chlorothoxyacetate
• CAS NO: 17229-14-0
• Molecular Formula: C₆H₁₁ClO₃
• Molecular Weight: 166.60274
• EINECS: 1592732-453-0
• Product Categories: Pharmaceutical Intermediates
• Mol File: 17229-14-0.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 228℃
• Flash Point: 96℃
• Appearance: /
• Density: 1.119
• Vapor Pressure: 0.074mmHg at 25°C
• Refractive Index: 1.439
• Storage Temp.: 2-8°C
• CAS DataBase Reference: Ethyl 2-chloroethoxyl acetic acid(CAS DataBase Reference)
• NIST Chemistry Reference: Ethyl 2-chloroethoxyl acetic acid(17229-14-0)
• EPA Substance Registry System: Ethyl 2-chloroethoxyl acetic acid(17229-14-0)

Safety Data

• Hazardous Substances Data: 17229-14-0(Hazardous Substances Data)

Usage

General Description

Ethyl 2-chloroethoxyl acetic acid, also known as ethyl 2-chloroethyl acetate, is a chemical compound with the molecular formula C6H11ClO3. It is an ester of acetic acid and is commonly used as an intermediate in the synthesis of pharmaceuticals and agrochemicals. This chemical is a colorless liquid with a fruity odor and is highly flammable. It is also known to be harmful if swallowed, inhaled, or in contact with the skin, and can cause irritation to the respiratory system, skin, and eyes. Ethyl 2-chloroethoxyl acetic acid is an important chemical in the manufacturing industry, but should be handled with care due to its toxic and flammable properties.

InChI:InChI=1/C6H11ClO3/c1-2-10-6(8)5-9-4-3-7/h2-5H2,1H3

Upstream product

• 105-36-2 ethyl bromoacetate 
• 107-07-3 2-chloro-ethanol 
• 64-17-5 ethanol 
• 3041-16-5 p-dioxanone 
• 144-55-8 sodium hydrogencarbonate 
• 628-89-7 2-(2-Chloroethoxy)ethanol 
• 57253-40-4 5-chloro-2,3-dihydro-1,4-dioxin 
• 75-21-8 oxirane 
• 105-39-5 chloroacetic acid ethyl ester 
• 31250-08-5 2-chloroethyl cyanomethyl ether 

Downstream Products

• 14869-41-1 (2-chloroethoxy)-acetic acid 

Relevant articles and documents

Novel bicyclic pyrazoles as potent ALK2 (R206H) inhibitors for the treatment of fibrodysplasia ossificans progressiva

Mutant activin receptor-like kinase-2 (ALK2) is associated with the pathogenesis of fibrodysplasia ossificans progressiva, making it an attractive target for therapeutic intervention. We synthesized a new series of bicyclic pyrazoles and evaluated their mutant ALK2 enzyme inhibitory activities, leading to the identification of 8 as the most potent inhibitor. This compound showed moderate microsomal metabolic stability and human ether-a-go-go related gene (hERG) safety. In C2C12 cells carrying mutant ALK2 (R206H), 8 efficiently inhibited the bone morphogenetic protein (BMP)-induced alkaline phosphatase activity.

Tetracyclic compounds having anti-allergic and anti-asthmatic activities and their use

Compounds of formula (I): STR1 in which: Q is nitrogen or =CH--; R1 and R2 are hydrogen, alkyl, alkoxy, hydroxy, trifluoromethyl or halogen; and R3 is a substituted alkyl groups or a pharmaceutically acceptable salt thereof have valuable anti-allergic and anti-asthmatic activities. The compounds are prepared by reacting a corresponding compound where R3 is replaced by a hydrogen atom with a compound to introduce the group R3.

2,6-Disubstituted penem compounds

This invention relates to 2-substituted and 2,6-disubstituted penem compounds of the formula STR1 wherein Y is hydrogen, halo or certain organic radicals and X represents certain hetero-interrupted substituted alkyl radicals. Also included in the invention are pharmaceutically acceptable salts of the above compounds and derivatives of the above compounds in which the carboxyl group at the 3-position is protected as by an easily removable ester protecting group. The compounds of the present invention are potent antibacterial agents or are of use as intermediates in the preparation of such agents.