312693-17-7

Usage

Uses

Used in Pharmaceutical Industry:
4-Methoxybenzylzinc chloride is used as a synthetic reagent for the preparation of various pharmaceuticals. Its ability to form carbon-carbon bonds and its compatibility with different functional groups make it a valuable component in the synthesis of complex organic molecules, contributing to the development of new drugs.
Used in Agrochemical Industry:
In the agrochemical industry, 4-Methoxybenzylzinc chloride is used as a key intermediate in the synthesis of agrochemicals. Its reactivity and stability allow for the creation of molecules with specific properties, enhancing the effectiveness of these chemicals in agricultural applications.
Used in Fine Chemicals Industry:
4-Methoxybenzylzinc chloride is employed as a versatile building block in the synthesis of fine chemicals. Its role in cross-coupling reactions, aldol reactions, and benzylations enables the production of a wide range of specialty chemicals with specific applications in various industries.
Used in Organic Synthesis Research:
As a powerful synthetic tool, 4-methoxybenzylzinc chloride is used in research for organic synthesis. Its unique properties and reactivity make it an essential component in the development of new methodologies and the synthesis of complex organic molecules for academic and industrial research.

InChI:InChI=1/C8H9O.ClH.Zn/c1-7-3-5-8(9-2)6-4-7;;/h3-6H,1H2,2H3;1H;/q-1;;+2/p-1/rC8H9O.ClZn/c1-7-3-5-8(9-2)6-4-7;1-2/h3-6H,1H2,2H3;/q-1;+1

Upstream product

• 104-92-7 1-bromo-4-methoxy-benzene 
• 7646-85-7 zinc(II) chloride 
• 824-94-2 p-methoxybenzyl chloride 
• 7440-66-6 zinc 

Relevant academic research and scientific papers

Asymmetric Synthesis of Fluorinated Allenes by Rhodium-Catalyzed Enantioselective Alkylation/Defluorination of Propargyl Difluorides with Alkylzincs

The reaction of propargyl difluorides R1CF2C≡CR2 with alkylzincs R3ZnCl giving axially chiral fluorinated allenes R1FC=C=CR2R3 with high enantioselectivity (up to 99 % ee) was found to be catalyzed by a chiral diene/rhodium complex. A key step in the catalytic cycle is selective elimination of one of the enantiotopic fluorides at the β-position of an alkenyl-Rh intermediate, which is generated by regioselective addition of R3-Rh onto the triple bond of the starting difluorides.

Stereoselective Cobalt-Catalyzed Cross-Coupling Reactions of Arylzinc Chlorides with α-Bromolactones and Related Derivatives

α-Bromolactones bearing a substituent in the β-position undergo a highly trans-diastereoselective arylation with arylzinc chlorides in the presence of 10-20% CoCl2 and 10-20% PPh3 in THF under mild conditions (25 °C, 16 h) leading to

Continuous preparation method of benzyl zinc halide and derivatives of benzyl zinc halide

The invention provides a continuous preparation method of benzyl zinc halide and derivatives of the benzyl zinc halide. According to the continuous preparation method, a continuous reactor is adoptedfor the reaction that zinc atoms are directly insert int

A practical cobalt-catalyzed cross-coupling of benzylic zinc reagents with aryl and heteroaryl bromides or chlorides

A catalytic system consisting of 5 mol% CoCl2 and 10 mol% isoquinoline allows a convenient cross-coupling of benzylic zinc reagents with various aryl and heteroaryl bromides or chlorides leading to polyfunctionalized diaryl- and aryl-heteroaryl-methane derivatives.