312710-48-8

Basic information

• Product Name: Butanoic acid, 3-[[(1,1-dimethylethoxy)carbonyl]amino]-4-(phenylmethoxy)-, methyl ester, (3R)-
• CAS NO: 312710-48-8
• Molecular Formula: C17H25NO5
• Molecular Weight: 323.389
• Mol File: 312710-48-8.mol

Chemical Properties

• CAS DataBase Reference: Butanoic acid, 3-[[(1,1-dimethylethoxy)carbonyl]amino]-4-(phenylmethoxy)-, methyl ester, (3R)-(CAS DataBase Reference)
• NIST Chemistry Reference: Butanoic acid, 3-[[(1,1-dimethylethoxy)carbonyl]amino]-4-(phenylmethoxy)-, methyl ester, (3R)-(312710-48-8)
• EPA Substance Registry System: Butanoic acid, 3-[[(1,1-dimethylethoxy)carbonyl]amino]-4-(phenylmethoxy)-, methyl ester, (3R)-(312710-48-8)

Safety Data

• Hazardous Substances Data: 312710-48-8(Hazardous Substances Data)

Upstream product

• 67-56-1 methanol 
• 193148-60-6 tert-butyl N-{(1S)-[(benzyloxy)methyl]-3-diazo-2-oxopropyl}carbamate 
• 23680-31-1 BOC-O-benzyl-L-serine 
• 218943-31-8 (R)-4-(benzyloxy)-3-{[(tert-butoxy)carbonyl]amino}butanoic acid 
• 74-88-4 methyl iodide 
• 279256-97-2 (R)-4-benzyloxy-3-(o-nitrobenzenesulfonamido)butanoic acid methyl ester 
• 261159-47-1 (4S)-4-(benzyloxymethyl)-oxetan-2-one 
• 24424-99-5 di-tert-butyl dicarbonate 
• 497847-07-1 (R)-3-Amino-4-benzyloxy-butyric acid methyl ester 

Downstream Products

• 312710-60-4 Boc-(2R,3R)-(α-CH2OH)-β^2,3-HSer(OBn)-β³-HLeu-OMe 
• 312710-59-1 (2R,3R)-4-Benzyloxy-3-tert-butoxycarbonylamino-2-hydroxymethyl-butyric acid 
• 312710-49-9 methyl (2R,3R)-4-(benzyloxy)-3-{[(tert-butoxy)carbonyl]amino}-2-(hydroxymethyl)butanoate 
• 401613-91-0 Boc-β³-HSer(OBn)-β³-HSer(OBn)-β³-HSer(OBn)-OMe 
• 401613-90-9 Boc-β³-HSer(OBn)-β³-HSer(OBn)-OMe 

Relevant articles and documents

ACYLSULFONAMIDE DERIVATIVES FOR TREATING SENESCENCE-ASSOCIATED DISEASES AND DISORDERS

Compounds represented by Formula (I) and (II) and salts thereof are described herein. The compounds or salts of Formula (I) and (II) may be used to treat senescence-associated diseases and disorders.

Divergent reaction pathways in amine additions to β-lactone electrophiles. An application to β-peptide synthesis

β-Lactone electrophiles are subject to regioselective addition-elimination (AE) or SN2 ring opening with various nitrogen-based nucleophiles. Primary and secondary amines promote AE ring opening to deliver products that are the functional equiv

Synthesis of cyclo-β-tripeptides and their biological in vitro evaluation as antiproliferatives against the growth of human cancer cell lines

A number of cyclo-β-tripeptides and their linear precursors were subjected to primary biological evaluation for cancer-cell growth inhibition (one-dose, three-cell essay), and the five most active ones were then tested in the anti-tumor screen of the National Cancer Institute (Bethesda, USA) with 60 human cancer cell lines. Growth inhibition values GI50 in the one-digit micromolar, and in one case in the nanomolar range were obtained. The effects show selectivities for certain types of cancer cells and for certain cell lines within these types; the screen includes leukemia, non-small-cell lung, colon, and central-nervous-system (CNS) cancer, melanoma, ovarian, renal, prostate, and breast cancer cell lines. The synthesis and full characterization of two new cyclo-β-peptides, (β3-HSer(OBn))3 (11) and (β3-HMet)3 (12) are described. Other cyclo-β-peptides included in this investigation are (βAsp(Bn))3 (13), (β-HGlu(Bn))3 (14), and (β-HAla)3 (16), compounds which had been previously prepared by us. Strongest activities were measured with the cyclo-β-peptides bearing benzyl-ester or benzyl-ether groups in the side chains. The cytotoxic activity of the compounds included in this investigation is much lower (LC50 > 100 μM) than their antiproliferative activity (GI50).