312746-18-2Relevant academic research and scientific papers
Cu(II) and Ni(II) complexes of novel three 2-{1'-phenyl-3'-(4''-halophenyl) -1 H-pyrazole-4-yl}-1 H -benzimidazoles: Synthesis and structural depiction
Maru, Minaxi S.,Shah, Manish K.
, p. 912 - 919 (2014)
Novel three 2-{1'-Phenyl-3'-(4''-halophenyl)-1H-pyrazole-4-yl}-1H- benzimidazoles (HBa-a-c) synthesized by the condensation of o-phenylenediamine and substituted-1H-pyrazole aldehydes in the presence of H2O2 through Ceric ammonium nitrate in catalytic amount and the nonchelated monodentate benzimidazoles complexes of 2-{1'-Phenyl-3'- (4''-halophenyl)-1H-pyrazole-4-yl}-1H-benzimidazoles were synthesized with a choice of metal salts in 2:1 mole ratio of ligand and metal salts, respectively, in ethanolic solution. The confirmed structures and characteristics of complexes were in good agreement with various physicochemical studies. The monodentate behavior of the ligands was proposed on the basis of spectral studies. The newly synthesized complexes possess octahedral and tetrahedral, square pyramidal and square planar geometry.
Synthesis and antioxidant activity of some new N-alkylated pyrazole-containing benzimidazoles
Bellam, Mahesh,Gundluru, Mohan,Sarva, Santhisudha,Chadive, Sridevi,Netala, Vasudeva Reddy,Tartte, Vijaya,Cirandur, Suresh Reddy
, p. 173 - 178 (2017)
[Figure not available: see fulltext.] A series of new N-substituted pyrazole-containing benzimidazoles was synthesized starting from 1,2-diaminobenzene and pyrazole-4-carbaldehyde in good yield. Antioxidant activity of all title compounds was assessed usi
Design, synthesis and in vitro antitumor evaluation of novel pyrazole-benzimidazole derivatives
Gao, Jin-Ming,Ji, Kegong,Liu, Rong-Chun,Ren, Bo,Tang, Jiang-Jiang
, (2021/06/03)
A series of novel pyrazole-benzimidazole derivatives (6–42) have been designed, synthesized and evaluated for their in vitro antiproliferative activity against the HCT116, MCF-7 and Huh-7 cell lines. Among them, compounds 17, 26 and 35 showed significant
Pyrazolylbenzo[d]imidazoles as new potent and selective inhibitors of carbonic anhydrase isoforms hCA IX and XII
Kumar, Satish,Ceruso, Mariangela,Tuccinardi, Tiziano,Supuran, Claudiu T.,Sharma, Pawan K.
, p. 2907 - 2913 (2016/06/13)
Novel pyrazolylbenzo[d]imidazole derivatives (2a-2f) were designed, synthesized and evaluated against four human carbonic anhydrase isoforms belonging to α family comprising of two cytosolic isoforms hCA I and II as well as two transmembrane tumor associated isoforms hCA IX and XII. Starting from these derivatives that showed high potency but low selectivity in favor of tumor associated isoforms hCA IX and XII, we investigated the impact of removing the sulfonamide group. Thus, analogs 3a-3f without sulfonamide moiety were synthesized and biological assay revealed a good activity as well as an excellent selectivity as inhibitors for tumor associated hCA IX and hCA XII and the same was analyzed by molecular docking studies.
