312752-85-5

Upstream product

• 721452-52-4 ethyl (R)-1-{2-[(4-fluorobenzoyl)amino]ethyl}piperidine-3-carboxylate 
• 403-43-0 4-fluorobenzoyl chloride 
• 95383-37-2 2-bromo-1-(4-fluorobenzamido)ethane 
• 1745-07-9 6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline 
• 721452-55-7 YM-234903 
• 2328-12-3 6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline monohydrochloride 

Relevant academic research and scientific papers

Development of a practical and scalable synthetic route to YM758 monophosphate, a novel If channel inhibitor

A novel, practical, and efficient synthesis of (-)-N-{2-[(R)-3-(6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline-2-carbonyl)piperidino]ethyl}-4-fluorobenzamide monophosphate (YM758 monophosphate, (R)-1·H3PO4 (Figure 1) is described. The

Novel denzamide derivatives and process for production thereof

There are provided a novel process for the production of an isoquinoline derivative having an inhibitory action for If current; a novel benzamide derivative or a salt thereof used for the production process; and a process for the production of the benzamide derivative or a salt thereof.

NOVEL CRYSTAL OF FLUOROBENZAMIDE DERIVATIVE

There are provided novel crystals of (-)-N-{2-[(R)-3-(6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline-2-carbonyl)piperidino]ethyl}-4-fluorobenzamide monophosphate.