312968-21-1

Usage

Uses

Used in Organic Synthesis:
1H-INDENE-2-BORONIC ACID is used as a reagent for the formation of carbon-carbon and carbon-heteroatom bonds. Its ability to selectively react with other organic compounds makes it a versatile building block in the synthesis of complex organic molecules.
Used in Pharmaceutical Synthesis:
In the pharmaceutical industry, 1H-INDENE-2-BORONIC ACID is used as a key intermediate in the synthesis of various drugs. Its unique reactivity allows for the creation of new molecular structures with potential therapeutic properties.
Used in Agrochemical Synthesis:
1H-INDENE-2-BORONIC ACID is also utilized in the development of agrochemicals, such as pesticides and herbicides. Its role in forming specific chemical bonds contributes to the design of effective and targeted agricultural products.
Used in Advanced Materials:
1H-INDENE-2-BORONIC ACID finds application in the synthesis of advanced materials, where its reactivity and functional group can be harnessed to create new materials with unique properties for various high-tech applications.

Upstream product

• 10485-09-3 2-bromoindene 
• 121-43-7 Trimethyl borate 
• 664327-47-3 indenyl magnesium bromide 

Downstream Products

• 79449-08-4 1-(4-(1H-inden-2-yl)phenyl)ethanone 
• 4505-48-0 2-phenylindene 
• 51220-31-6 (1H-inden-2-yl)dimethyl(phenyl)silane 
• 41712-14-5 indene-2-carboxylic acid 
• 95414-68-9 imino(phenyl)(trifluoromethyl)-λ⁶-sulfanone 
• 1421374-57-3 2-(2-chlorophenyl)-1H-indene 

Relevant academic research and scientific papers

Copper-Catalyzed [2+2+2] Modular Synthesis of Multisubstituted Pyridines: Alkenylation of Nitriles with Vinyliodonium Salts

A [2+2+2] modular synthesis of multisubstituted pyridines, with excellent regioselectivity, has been realized by copper catalysisand involves three distinct components: vinyliodonium salts, nitriles, and alkynes. The reactions proceeded with the facile formation of an aza-butadienylium intermediate by alkenylation of the nitrile with a vinyliodonium salt. Moreover, the alkynes in the reaction were extended to alkenes, which are an advantage of expense and relative scarceness of alkynes.

THIAZOLE DERIVATIVES AS PROTEIN KINASE INHIBITORS

The present invention relates to novel Thiazole Derivatives, compositions comprising the Thiazole Derivatives, and methods for using the Thiazole Derivatives for treating or preventing a proliferative disorder, an anti-proliferative disorder, inflammation, arthritis, a central nervous system disorder, a cardiovascular disease, alopecia, a neuronal disease, an ischemic injury, a viral infection, a fungal infection, or a disorder related to the activity of a protein kinase.

Indenyl compounds for the polymerization of olefins

Indenyl compound of formula (1) wherein: M is a transition metal from the lanthanides or from group 3, 4, 5 or 6 of the Periodic System of Elements, Q is an anionic ligand to M, k is the number of Q groups, R is a bridging group and Z and X are substituents, wherein R contains at least one sp2-hybridized carbon atom that is bonded to the indenyl group at the 2-position with the exclusion of Ti(deshydronorbiphenacene) dichloride.

A Suzuki coupling based route to 2,2′-bis(2-indenyl)biphenyl derivatives

Because of the promising performance in olefin polymerization of 2,2′-bis(2-indenyldiyl)biphenyl zirconium dichloride, we developed a new and broadly applicable route to 2,2′-bis(2-indenyl)biphenyl derivatives. Reaction of the known 2,2′-diiodobiphenyl (26) with the new 2-indenyl boronic acid (23) did not result in the desired 2,2′-bis(2-indenyl)biphenyl (10); instead an isomer thereof, (spiro-1,1-(2,2′-biphenyl)-2-(2-indenyl)indane) (27), was obtained. It was found that compound 10 could be made via a palladium-catalyzed reaction of 2,2-biphenyldiboronic acid (31) with 2-bromoindene (21) under standard Suzuki reaction conditions. However, the yield of this reaction was low at low palladium catalyst loadings, due to a competitive hydrolysis reaction of 2,2-biphenyldiboronic acid (31). HTE techniques were used to find an economically viable protocol. Thus, use of the commercially available 1.0 molar solution of (n-Bu)4NOH in methanol with cosolvent toluene led to precipitation of the pure product in a fast and clean reaction, using only 0.7 mol % (0.35 mol % per C-C) of the expensive palladium catalyst.