313058-67-2Relevant academic research and scientific papers
Mild, Redox-Neutral Formylation of Aryl Chlorides through the Photocatalytic Generation of Chlorine Radicals
Nielsen, Matthew K.,Shields, Benjamin J.,Liu, Junyi,Williams, Michael J.,Zacuto, Michael J.,Doyle, Abigail G.
supporting information, p. 7191 - 7194 (2017/06/13)
We report a redox-neutral formylation of aryl chlorides that proceeds through selective 2-functionalization of 1,3-dioxolane through nickel and photoredox catalysis. This scalable benchtop approach provides a distinct advantage over traditional reductive carbonylation in that no carbon monoxide, pressurized gas, or stoichiometric reductant is employed. The mild conditions give unprecedented scope from abundant and complex aryl chloride starting materials.
Integrated chemical process: One-pot aromatization of cyclic enones by the double elimination methodology
Orita, Akihiro,Yaruva, Jayamma,Otera, Junzo
, p. 2267 - 2270 (2007/10/03)
A variety of aromatic hydrocarbons bearing multiple alkyl substituents are accessible with perfect regiocontrol in a one-pot reaction starting from cyclo-hexenones and their aromatic analogues [Eq. (1)]. The present methodology can be further extended to the synthesis of polycyclic aromatic hydrocarbons. The drawbacks encountered in the Friedel-Crafts reaction are resolved since the reaction proceeds under basic conditions.
