313648-72-5

Upstream product

• 121-91-5 isophthalic acid 
• 23351-91-9 5-bromoisophthalic acid 
• 51760-21-5 dimethyl 5-bromoisophthalate 
• 944392-68-1 dimethyl 5-(pinacolboryl)isophthalate 
• 1066-54-2 trimethylsilylacetylene 
• 13036-02-7 Dimethyl 5-hydroxyisophthalate 
• 99-27-4 dimethyl 5-aminoisophthalate 
• 51839-15-7 5-iodo-isophthalic acid dimethyl ester 
• 168619-21-4 3,5-bis(methoxycarbonyl)phenyl trifluoromethanesulfonate 

Downstream Products

• 1201635-31-5 1,3-bis(3,5-bis(methoxycarbonyl)phenylethynyl)benzene 
• 1263078-32-5 1,3-bis(2-(3,5-bis(methoxycarbonyl)phenyl)ethyl)benzene 
• 1263078-33-6 1,3-bis(2-(3,5-bis(bromomethyl)phenyl)ethyl)benzene 
• 1311146-60-7 5-(2-(4-carboxyphenyl)ethynyl)benzene-1,3-dioic acid 
• 1314941-51-9 tetramethyl 1,1'-butadiynebenzene-3,3',5,5'-tetracarboxylate 
• 1350901-58-4 tetramethyl 5,5'-((([2,2'-bipyridine]-4,4'-diylbis(ethyne-2,1-diyl))bis(2,5-dibutoxy-4,1-phenylene))bis(ethyne-2,1-diyl))diisophthalate 
• 1444603-92-2 dimethyl 5-((2,5-dibutoxy-4-ethynylphenyl)ethynyl)isophthalate 

Relevant academic research and scientific papers

Remote stabilization of copper paddlewheel based molecular building blocks in metal-organic frameworks

Copper paddlewheel based molecular building blocks (MBBs) are ubiquitous and have been widely employed for the construction of highly porous metal-organic frameworks (MOFs). However, most copper paddlewheel based MOFs fail to retain their structural integ

Improving crystallization and processability of PBS: Via slight cross-linking

To improve the processability and crystallization of poly(butylene succinate) (PBS), a cross-linkable comonomer containing an alkynyl group, named 5-(2-(trimethylsilyl)ethynyl)isophthalate (DTS) was synthesized and copolymerized with dimethyl succinate and 1,4-butanediol to prepare a series of slightly cross-linked PBS copolyesters (PBDTSx). Due to the very low cross-linking degree, PBDTSx do not form gels when the DTS molar content is lower than 1.0%, and this made them keep good solubility and reprocessability. The cross-linking degree of DTS in PBDTSx is determined by NMR spectra. GPC data show that the Mw values of the copolyesters are higher than 23 × 104 g mol-1, and increase with the increase of DTS content. The thermal stability, crystallization, rheological behaviours, and mechanical properties of PBDTSx were investigated. Compared to neat PBS, PBDTSx have greatly increased crystallization rates because of promoted nucleation of the cross-linking domains. The elongation at break of PBDTSx drops slightly, while the Young's modulus increases. The rheological behaviours indicate that PBDTSx have higher melt viscosity than neat PBS even at a high shear rate, meaning that they will have better blow moulding processability. This work demonstrates that via controlling tiny cross-linking during the polymerization of PBS, the properties and processability of PBS can be improved, and this method overcomes the defects caused by traditional post cross-linking.

Catalytic Performance and Electrophoretic Behavior of an Yttrium-Organic Framework Based on a Tricarboxylic Asymmetric Alkyne

A new Y-based metal-organic framework (MOF) GR-MOF-6 with a chemical formula of {[YL(DMF)2]·(DMF)}n {H3L = 5-[(4-carboxyphenyl)ethynyl] isophthalic acid; DMF = N,N-dimethylformamide} has been prepared by a solvothermal route. Structural characterization reveals that this novel material is a three-dimensional MOF in which the coordination of the tritopic ligand to Y(III) metal ions leads to an intercrossing channel system extending over three dimensions. This material has proven to be a very efficient catalyst in the cyanosilylation of carbonyls, ranking second in catalytic activity among the reported rare earth metal-based MOFs described so far but with the lowest required catalyst loading. In addition, its electrophoretic behavior has been studied in depth, providing a zero-charge point between pH 4 and 5, a peak electrophoretic mobility of -1.553 μm cm V-1 s-1, and a ζ potential of -19.8 mV at pH 10.

Two isostructural URJC-4 materials: From hydrogen physisorption to heterogeneous reductive amination through hydrogen molecule activation at low pressure

Herein, two novel isostructural metal-organic frameworks (MOFs) M-URJC-4 (M = Co, Ni; URJC = "Universidad Rey Juan Carlos") with open metal sites, permanent microposity, and large surface areas and pore volumes have been developed. These novel MOFs, with polyhedral morphology, crystallize in the monoclinic P21/c space group, exhibiting a three-dimensional structure with microporous channels along the c axis. Initially, they were fully characterized and tested in hydrogen (H2) adsorption at different conditions of temperature and pressure. The physisorption capacities of both materials surpassed the gravimetric H2 uptake shown by most MOF materials under the same conditions. On the basis of the outstanding adsorption properties, the Ni-URJC-4 material was used as a catalyst in a one-pot reductive amination reaction using various carbonyl compounds and primary amines. A possible chemical pathway to obtain secondary amines was proposed via imine formation, and remarkable performances were accomplished. This work evidences the dual ability of M-URJC-4 materials to be used as a H2 adsorbent and a catalyst in reductive amination reactions, activating molecular H2 at low pressures for the reduction of C=N double bonds and providing reference structural features for the design of new versatile heterogeneous materials for industrial application.

Tailoring the pore geometry and chemistry in microporous metal-organic frameworks for high methane storage working capacity

We realized that tailoring the pore size/geometry and chemistry, by virtue of alkynyl or naphthalene replacing phenyl within a series of isomorphic MOFs, can optimize methane storage working capacities, affording an exceptionally high working capacity of

Isosteric Substitution of 4 H-1,2,4-Triazole by 1 H-1,2,3-Triazole in Isophthalic Derivative Enabled Hydrogel Formation for Controlled Drug Delivery

In this work, we demonstrated that the simple substitution of the 1,2,4-triazole moiety in 5-(4H-1,2,4-triazol-4-yl)isophthalic acid (5-TIA) by the 1H-1,2,3-triazol-5-yl unit enables the preparation of a hydrogelator (click-TIA). In sharp contrast to 5-TIA, its isostere click-TIA undergoes self-assembly in water upon sonication, leading to the formation of stable supramolecular viscoelastic hydrogels with a critical gelation concentration of 6 g/L. Hydrogels made of click-TIA as well as hybrid hydrogels made of the mixture click-TIA + 5-TIA (molar ratio 1:0.2) were used to compare different properties of the materials (i.e., rheological properties, thermal properties, mechanical stability, morphology). In terms of toxicity, neither click-TIA nor 5-TIA showed cytotoxic effects on cellular viability of HeLa cells up to 2.3 × 10-3 g/L when compared to untreated cells incubated with DMSO. Furthermore, the hydrogels were used for the encapsulation and in vitro controlled release of oxytetracycline that followed first-order kinetics. For the hydrogel made of click-TIA, a maximum drug release of ～60% was reached after ～8 h within a pH range between 6.5 and 10. However, the release rate was reduced to approximately half of its value at pH values between 1.2 and 5.0, whereas the use of hybrid hydrogels made of click-TIA + 5-TIA allowed to reduce the original rate at pH ≤ 6.5.

OLIGONUCLEOTIDE DERIVATIVE, OLIGONUCLEOTIDE CONSTRUCT USING THE SAME, AND METHODS FOR PRODUCING THEM

The oligonucleotide derivative of the present invention is represented by Formula (1). This derivative is considered to be introduced into cells by binding of its amino sugar chain moiety to a ligand on cell surfaces, and have selective drug delivery function. The oligonucleotide derivative can be easily synthesized and introduced into cells without using a lipofection reagent. wherein—A and B are independently modified or unmodified oligonucleotides whose total chain length is 3 or more, and A and B do not contain hydroxyl groups at 3′ and 5′ ends of the oligonucleotide; S represents a sugar substituent, a peptide chain, or a tocopherol-binding group; and an alkyl group may be bound instead of hydrogen bound to a benzene ring.

Two Functional Porous Metal-Organic Frameworks Constructed from Expanded Tetracarboxylates for Gas Adsorption and Organosulfurs Removal

Two fof-type porous metal-organic frameworks (MOFs), [Cu2(bdfdpa)(H2O)2]·8DMF·2H2O (JLU-Liu29) and [Cu2(btadpa)(H2O)2]·7DMF·8H2O (JLU-Liu30) (H4bdfdpa = 5,5

A NbO-type metal-organic framework exhibiting high deliverable capacity for methane storage

A copper-based NbO-type metal-organic framework ZJNU-50 constructed from a tetracarboxylate incorporating phenylethyne as a spacer exhibited an exceptionally high methane working capacity of 184 cm3 (STP) cm-3 for methane storage. The value is among the highest reported for MOF materials. This journal is

Homoleptic "star" Ru(II) polypyridyl complexes: Shielded chromophores to study charge-transfer at the sensitizer-TiO2 interface

Three homoleptic star-shaped ruthenium polypyridyl complexes, termed Star YZ1, Star YZ2, and Star YZ3, where the Ru(II) center is coordinated to three bipyridine ligands each carrying two oligo(phenylene ethynylene) (OPE) rigid linker units terminating wi