313657-75-9

Usage

Uses

Used in Pharmaceutical Industry:
(R)-4-N-TRITYL-2-METHYL PIPERAZINE is used as a key intermediate in the synthesis of pharmaceutical compounds for its role in the development of new drugs. It is particularly valuable in medicinal chemistry for its capacity to contribute to the creation of therapeutic agents with novel mechanisms of action.
Used in Drug Discovery:
(R)-4-N-TRITYL-2-METHYL PIPERAZINE is utilized as a building block in drug discovery processes, where its unique structural features allow for the design and synthesis of molecules with potential pharmacological properties. Its interaction with biological targets is crucial for identifying new leads and optimizing drug candidates for various therapeutic areas.

InChI:InChI=1/C24H26N2/c1-20-19-26(18-17-25-20)24(21-11-5-2-6-12-21,22-13-7-3-8-14-22)23-15-9-4-10-16-23/h2-16,20,25H,17-19H2,1H3/t20-/m0/s1

Upstream product

• 75336-86-6 (2R)-methylpiperazine 
• 76-83-5 trityl chloride 
• 109-07-9 (RS)-2-methylpiperazine 
• 126458-16-0 (R)-2-methylpiperazine, L-tartrate 

Downstream Products

• 531503-76-1 (R)-1-(3-chloro-2-pyrazinyl)-2-methyl-4-tritylpiperazine 
• 313657-76-0 (R)-1-(3-chloro-2-pyrazinyl)-2-methylpiperazine 
• 639029-52-0 (2R)-1-(3-chloro-2-pyrazinyl)-2-methylpiperazine, hydrochloride 

Relevant academic research and scientific papers

Synthesis of PNU-243922 labelled with 14C

The arylpiperazine PNU-243922 (1) has been labelled with 14C. A two-step sequence starting from the 14C labelled alcohol 6a led to radiochemically pure (> 98%) [14C]PNU-243922 with a specific activity of 546 MBq/mmol. Copyright

Novel compounds and their use

Compounds of the general formula (I): wherein R1, R2, R3 and R4 are as described in the specification. Further included are pharmaceutical compositions comprising the compounds, processes for their preparation,

NOVEL PROCESS

The present invention relates to a process for the preparation of compounds which are therapeutically active in the central nervous system. In one aspect, the invention relates to a process for the preparation of compounds of the general formula (I). The invention also relates to (2R)-1-(3-chloro-2-pyrazinyl)-2-methylpiperazine, hydrochloride and a process for preparing the same. Another object of the present invention is a compound of the formula (I). Another object of the present invention is a method for the treatment or prophylaxis of a serotonin-related disorder, comprising administering to a subject in need thereof an effective amount of the compound above; as well as the use of said compound to manufacture a medicament for the treatment of a serotonin-related disorder.

Certain aryl-aliphatic and heteroaryl-aliphatic piperazinyl pyrazines and their use in the treatment of serotonin-related diseases

Compounds of the general formula (I): wherein the variables are as defined in the specification are useful for the prophylaxis or treatment of serotonin-related, especially 5-HT2receptor-related, diseases in human beings or animals, particularly diseases related to the 5-HT2creceptor, especially diseases such as eating disorders, memory disorders, schizophrenia, mood disorders, anxiety disorders, pain, sexual dysfunctionions, and urinary disorders.